Walking, Brain and Functional Magnetic Resonance Imaging Study of Motor Representations in Healthy Subjects and Amnestic MCI
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Mild Cognitive Impairment
- Sponsor
- University Hospital, Angers
- Enrollment
- 97
- Locations
- 1
- Primary Endpoint
- Review and compare mapping cerebral activation in brain MRI
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
Walking, Brain and Functional Magnetic Resonance Imaging Study of motor representations in healthy subjects and amnesic MCI.
Detailed Description
Review and compare mapping brain activation in Magnetic Resonance Imaging about healthy subjects according to age (\<40 years and\> 60 years) and MCI through the combination of two paradigms: on mechanically simulated by Korvit® boots and imagination of the walk.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Obtaining the signature of consent to participation in the study
- •Age above 18 years
- •Lack dementia as NICDS-ADRDA criteria
- •Lack of pre-existing musculoskeletal disorders, regardless of the cause (except MCI).
- •Absence of a history of stroke or other cerebrovascular disease with spinal sensorimotor sequelae.
- •No cons-indication for performing a brain MRI.
- •Witennses, population of young (\<40 years)
- •Witnesses ,population of older subjects (\> 60 years)
- •Witnesses Lack of MCI
- •MCI patients, criteria MCI criteria according to Dubois
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Review and compare mapping cerebral activation in brain MRI
Time Frame: One day
Review and compare mapping brain activation in healthy about MRI according to age (\<40 years and\> 60 years) and MCI through the combination of two paradigms: on mechanically simulated by Korvit® boots and imagination the walk. The primary endpoint is the analysis of fMRI brain mapping in accordance with the different paradigms of acquisition. The MRI data will be the subject of a specific statistical treatment, via dedicated software, which will be implemented under the control of the investigators who have conducted such an fMRI analysis in previous studies. Various brain mapping can be established from the data collected. It may include statistical comparisons between different preselected regions, and different experimental conditions, or correlation studies between brain activation and clinical parameters.
Secondary Outcomes
- Review and compare mapping brain activation in healthy subjects and MCI MRI in imagination alone walking.(One day)
- Study of differences in terms of activation of brain mapping(One day)
- study of functional connectivity of sensorimotor cortex obtained by fMRI resting in the subject MCI.(One day)
- study of the potential effects on muscle activation, and autonomic nervous system(One day)