Study of Motor Representations in Healthy Subjects and Amnestic MCI
- Conditions
- Mild Cognitive Impairment
- Registration Number
- NCT02574182
- Lead Sponsor
- University Hospital, Angers
- Brief Summary
Walking, Brain and Functional Magnetic Resonance Imaging Study of motor representations in healthy subjects and amnesic MCI.
- Detailed Description
Review and compare mapping brain activation in Magnetic Resonance Imaging about healthy subjects according to age (\<40 years and\> 60 years) and MCI through the combination of two paradigms: on mechanically simulated by Korvit® boots and imagination of the walk.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 97
- Obtaining the signature of consent to participation in the study
- Age above 18 years
- Lack dementia as NICDS-ADRDA criteria
- Lack of pre-existing musculoskeletal disorders, regardless of the cause (except MCI).
- Absence of a history of stroke or other cerebrovascular disease with spinal sensorimotor sequelae.
- No cons-indication for performing a brain MRI.
- Witennses, population of young (<40 years)
- Witnesses ,population of older subjects (> 60 years)
- Witnesses Lack of MCI
- MCI patients, criteria MCI criteria according to Dubois
Exclusion Criteria :
- Refusal of MRI.
- Contraindications to brain MRI.
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Review and compare mapping cerebral activation in brain MRI One day Review and compare mapping brain activation in healthy about MRI according to age (\<40 years and\> 60 years) and MCI through the combination of two paradigms: on mechanically simulated by Korvit® boots and imagination the walk. The primary endpoint is the analysis of fMRI brain mapping in accordance with the different paradigms of acquisition. The MRI data will be the subject of a specific statistical treatment, via dedicated software, which will be implemented under the control of the investigators who have conducted such an fMRI analysis in previous studies. Various brain mapping can be established from the data collected. It may include statistical comparisons between different preselected regions, and different experimental conditions, or correlation studies between brain activation and clinical parameters.
- Secondary Outcome Measures
Name Time Method Review and compare mapping brain activation in healthy subjects and MCI MRI in imagination alone walking. One day Review and compare mapping brain activation in healthy subjects and MCI MRI in imagination alone walking. the secondary endpoint will be the analysis of spatiotemporal gait parameters
Study of differences in terms of activation of brain mapping One day Study of differences in terms of activation of brain mapping between mechanical stimulation task arch simulating the place of the step (pace to 120 steps per minute) and a random mechanical stimulation (not reproducing the place of the pitch) . the secondary endpoint will be the analysis of spatiotemporal gait parameters
study of functional connectivity of sensorimotor cortex obtained by fMRI resting in the subject MCI. One day study of functional connectivity of sensorimotor cortex obtained by fMRI resting in the subject MCI. the secondary endpoint will be the analysis of spatiotemporal gait parameters
study of the potential effects on muscle activation, and autonomic nervous system One day study of the potential effects on muscle activation, and autonomic nervous system of plantar mechanical stimulation reproducing walking. the secondary endpoint will be the analysis of spatiotemporal gait parameters
Trial Locations
- Locations (1)
University Hospital Angers
🇫🇷Angers, Pays De La Loire, France
University Hospital Angers🇫🇷Angers, Pays De La Loire, France