Pretreatment upper-GI cancer organoid models for tailoring neoadjuvant treatment regimens
Recruiting
- Conditions
- esophageal cancergastric cancer1001799010017991
- Registration Number
- NL-OMON49596
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 320
Inclusion Criteria
Patients with histologically proven adeno- or squamous cell carcinoma of the
stomach or esophagus who are eligible for treatment with curative intent.
Signed informed consent.
Exclusion Criteria
- Inability to undergo gastroduodenoscopy
- Severe coagulopathy with uacceptable risk of bleeding due to biopsy
procurement
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Correlation between the in vitro respons of the organoid and the in vivo<br /><br>respons in the patient to the established neoadjuvant treatment regimens</p><br>
- Secondary Outcome Measures
Name Time Method <p>Identification of (epi)genetic differences on the DNA, RNA or protein level<br /><br>between the organoids of patients with response and non-response, as well as<br /><br>organoids from the same patient derived before and after treatment. </p><br>