Association of Anticholinergic Burden With Onset of Delirium in Older Adults With Alzheimer Dementia:
- Conditions
- Anticholinergic Adverse ReactionDeliriumAlzheimer Disease
- Interventions
- Drug: Anticholinergic burden
- Registration Number
- NCT05055895
- Lead Sponsor
- Gulhane Training and Research Hospital
- Brief Summary
Drugs with anticholinergic properties are commonly prescribed to older persons despite growing evidence of their significant adverse effects. However, limited data are available concerning their contribution to time of onset of delirium. This study aimed to determine the potential association of higher anticholinergic burden to early-onset of delirium superimposed dementia in the older adult.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 450
Inclusion Criteria
- 65 years and older and diagnosis or fellow-up of Alzhemier dementia in outpatient clinic.
Exclusion Criteria
- The patients with a history of other than Alzhemier dementia or neurodegenerative disease (epilepsy, multiple sclerosis, Parkinson disease, etc.), terminal illness (malignancy, advanced organ failure) were excluded.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description early onset deliryum on dementia Anticholinergic burden It was earlier than The median time of onset of delirium superimposed dementia Delirium on dementia (normal) Anticholinergic burden It was equal or later than The median time of onset of delirium superimposed dementia
- Primary Outcome Measures
Name Time Method Time onset of delirium superimposed dementia 12 month First attack of delirium onset
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Gulhane training and research hospital
🇹🇷Ankara, Turkey