Association of Anticholinergic Burden With Onset of Delirium in Older Adults With Alzheimer Dementia: A Retrospective Cohort Study
Overview
- Phase
- Not Applicable
- Intervention
- Anticholinergic burden
- Conditions
- Delirium
- Sponsor
- Gulhane Training and Research Hospital
- Enrollment
- 450
- Locations
- 1
- Primary Endpoint
- Time onset of delirium superimposed dementia
- Last Updated
- 4 years ago
Overview
Brief Summary
Drugs with anticholinergic properties are commonly prescribed to older persons despite growing evidence of their significant adverse effects. However, limited data are available concerning their contribution to time of onset of delirium. This study aimed to determine the potential association of higher anticholinergic burden to early-onset of delirium superimposed dementia in the older adult.
Investigators
Bilal Katipoglu
Geriatric
Gulhane Training and Research Hospital
Eligibility Criteria
Inclusion Criteria
- •65 years and older and diagnosis or fellow-up of Alzhemier dementia in outpatient clinic.
Exclusion Criteria
- •The patients with a history of other than Alzhemier dementia or neurodegenerative disease (epilepsy, multiple sclerosis, Parkinson disease, etc.), terminal illness (malignancy, advanced organ failure) were excluded.
Arms & Interventions
early onset deliryum on dementia
It was earlier than The median time of onset of delirium superimposed dementia
Intervention: Anticholinergic burden
Delirium on dementia (normal)
It was equal or later than The median time of onset of delirium superimposed dementia
Intervention: Anticholinergic burden
Outcomes
Primary Outcomes
Time onset of delirium superimposed dementia
Time Frame: 12 month
First attack of delirium onset