Association of Anticholinergic Burden With Onset of Delirium in Older Adults With Alzheimer Dementia:

• Conditions: Anticholinergic Adverse Reaction; Delirium; Alzheimer Disease
• Interventions: Drug: Anticholinergic burden

• Registration Number: NCT05055895
• Lead Sponsor: Gulhane Training and Research Hospital

Brief Summary

Drugs with anticholinergic properties are commonly prescribed to older persons despite growing evidence of their significant adverse effects. However, limited data are available concerning their contribution to time of onset of delirium. This study aimed to determine the potential association of higher anticholinergic burden to early-onset of delirium superimposed dementia in the older adult.

Detailed Description

Not available

Study Timeline

• Study Start: 2005-01-01
• Primary Completion: 2021-06
• Status Verified: 2021-09
• Study First Submitted: 2021-09-15
• Study First Submitted QC: 2021-09-15
• Last Update Submitted: 2021-09-15
• Study First Posted: 2021-09-24
• Last Update Posted: 2021-09-24
• Study Completion: 2022-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 450

Inclusion Criteria

• 65 years and older and diagnosis or fellow-up of Alzhemier dementia in outpatient clinic.

Exclusion Criteria

• The patients with a history of other than Alzhemier dementia or neurodegenerative disease (epilepsy, multiple sclerosis, Parkinson disease, etc.), terminal illness (malignancy, advanced organ failure) were excluded.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
early onset deliryum on dementia	Anticholinergic burden	It was earlier than The median time of onset of delirium superimposed dementia
Delirium on dementia (normal)	Anticholinergic burden	It was equal or later than The median time of onset of delirium superimposed dementia

Primary Outcome Measures

Name	Time	Method
Time onset of delirium superimposed dementia	12 month	First attack of delirium onset

Trial Locations

Locations (1)

Gulhane training and research hospital; 🇹🇷 Ankara, Turkey