Association of Anticholinergic Burden With Onset of Delirium in Older Adults With Alzheimer Dementia: A Retrospective Cohort Study
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 450
- 试验地点
- 1
- 主要终点
- Time onset of delirium superimposed dementia
研究概览
简要总结
Drugs with anticholinergic properties are commonly prescribed to older persons despite growing evidence of their significant adverse effects. However, limited data are available concerning their contribution to time of onset of delirium. This study aimed to determine the potential association of higher anticholinergic burden to early-onset of delirium superimposed dementia in the older adult.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •65 years and older and diagnosis or fellow-up of Alzhemier dementia in outpatient clinic.
排除标准
- •The patients with a history of other than Alzhemier dementia or neurodegenerative disease (epilepsy, multiple sclerosis, Parkinson disease, etc.), terminal illness (malignancy, advanced organ failure) were excluded.
研究组 & 干预措施
early onset deliryum on dementia
It was earlier than The median time of onset of delirium superimposed dementia
干预措施: Anticholinergic burden (Drug)
Delirium on dementia (normal)
It was equal or later than The median time of onset of delirium superimposed dementia
干预措施: Anticholinergic burden (Drug)
结局指标
主要结局
Time onset of delirium superimposed dementia
时间窗: 12 month
First attack of delirium onset
次要结局
未报告次要终点
研究者
Bilal Katipoglu
Geriatric
Gulhane Training and Research Hospital