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Clinical Trials/CTRI/2025/12/099031
CTRI/2025/12/099031Not yet recruitingPhase 4

Sugammadex vs Neostigmine for Reversal of Neuromuscular Blockade: Recovery Profile and Postoperative Complication

Vinayaka Missions Kirupananda Variyar Medical College and Hospitals1 site in 1 country60 target enrollmentStarted: December 25, 2025Last updated:

Trial Snapshot

Phase
Phase 4
Status
Not yet recruiting
Sponsor
Enrollment
60
Locations
1

Study Overview

Brief Summary

This study compares Sugammadex and Neostigmine for the reversal of neuromuscular blockade in patients undergoing general anesthesia. The aim is to evaluate which drug provides faster and more reliable recovery of muscle function and to assess the incidence of postoperative complications. The primary outcome is the time taken to achieve adequate neuromuscular recovery after administration of the reversal agent. Secondary outcomes include extubation time, return of clinical recovery signs, and postoperative events such as nausea, vomiting, desaturation, bradycardia, diplopia, and urinary retention during the first twenty four hours. This study will help determine whether Sugammadex offers significant clinical advantages over neostigmine in routine anesthesia practice.

Study Design

Study Type
Interventional
Allocation
Randomized
Masking
Participant and Outcome Assessor Blinded

Eligibility Criteria

Ages
18.00 Year(s) to 65.00 Year(s) (—)
Sex
All

Inclusion Criteria

  • 1.ASA I and II 2.Elective surgeries with vecuronium 3.Informed consent.

Exclusion Criteria

  • 1.Neuromuscular disorders 2.Hepatic/renal dysfunction 3.Known allergy to study drugs 4.Pregnancy/lactation.

Investigators

Sponsor
Vinayaka Missions Kirupananda Variyar Medical College and Hospitals
Sponsor Class
Private medical college
Responsible Party
Principal Investigator
Principal Investigator

Dr S Shanu

Vinayaka Missions Kirupananda Variyar Medical College and Hospitals

Study Sites (1)

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