NL-OMON37368CompletedPhase 2
Effects of levosimendan on diaphragm function in mechanically ventilated patients - Levosimendan in mechanically ventilated patients
niversitair Medisch Centrum Sint Radboud0 sites42 target enrollmentStarted: TBDLast updated:
Conditions
Trial Snapshot
- Phase
- Phase 2
- Status
- Completed
- Sponsor
- Enrollment
- 42
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Ages
- 18 to 99 (—)
Inclusion Criteria
- •age >18 year
- •mechanical ventilation for at least 3 days
- •PaO2/FiO2 ratio >200 mmHg
- •Ventilatory settings: Positive End Expiratory Pressure <=10 cmH2O, Pressure Support <= 10 cmH2O.
Exclusion Criteria
- •pre-existent muscle disease (congenital or acquired) or diseases / disorders know to be associated with myopathy including auto-immune diseases.
- •pre-existent cardiac disease (based on history, electrocardiography and transthoracic echocardiography)
- •upper airway / esophageal pathology (i.e. recent surgery, esophageal varices, diaphragmatic hernia)
- •phrenic nerve lesions
- •pregnancy, breast feeding
- •severe renal failure (serum creatinine > 450 µmol/L)
- •severe hepatic failure
- •recent (within 5 days) nasal bleeding
Investigators
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