Study of Erythrocyte Parameters and Hypercoagulability in Sickle Cell Disease
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Sickle Cell Disease
- Sponsor
- BILLOIR
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- Hospitalisation for Vaso-occlusive crisis within one years
- Status
- Recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
Sickle cell disease (SCD) is an inherited haemoglobinopathy disorder caused by mutations in HBB gene with amino-acid substitution on β globin chain. The consequence is synthesis of altered haemoglobin S (HbS) which polymerises in red blood cell (RBC) at deoxygenated state. SCD is associated with chronic haemolytic anaemia, vaso-occlusive crisis (VOC) leading to frequent hospitalisation.
The aim of the study was to to investigate whether a combination of routine laboratory biomarkers of haemolysis could be used to predict VOC development in confirmed SCD patients.
Investigators
BILLOIR
Associate Professor
University Hospital, Rouen
Eligibility Criteria
Inclusion Criteria
- •Sickle cell disease
Exclusion Criteria
- •\<18 years
- •pregnancy
- •Patient under protective guardianship or curatorship
Outcomes
Primary Outcomes
Hospitalisation for Vaso-occlusive crisis within one years
Time Frame: 1 year
Following injury consultation, evaluation of biological markers predicting vaso-occlusive crisis requiring hospitalisation in the year