Study of Erythrocyte Parameters and Hypercoagulability in Sickle Cell Disease
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Hospitalisation for Vaso-occlusive crisis within one years
研究概览
简要总结
Sickle cell disease (SCD) is an inherited haemoglobinopathy disorder caused by mutations in HBB gene with amino-acid substitution on β globin chain. The consequence is synthesis of altered haemoglobin S (HbS) which polymerises in red blood cell (RBC) at deoxygenated state. SCD is associated with chronic haemolytic anaemia, vaso-occlusive crisis (VOC) leading to frequent hospitalisation.
The aim of the study was to to investigate whether a combination of routine laboratory biomarkers of haemolysis could be used to predict VOC development in confirmed SCD patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Sickle cell disease
排除标准
- •<18 years
- •pregnancy
- •Patient under protective guardianship or curatorship
结局指标
主要结局
Hospitalisation for Vaso-occlusive crisis within one years
时间窗: 1 year
Following injury consultation, evaluation of biological markers predicting vaso-occlusive crisis requiring hospitalisation in the year
次要结局
未报告次要终点
研究者
BILLOIR
Associate Professor
University Hospital, Rouen