Effects Of Propofol-Dexmedetomıdıne And Propofol- Remıfentanıl In Hysteroscopıc Operations.
- Conditions
- Deep SedationAmbulatory SurgeryAmbulatory Surgical Procedure
- Interventions
- Combination Product: Propofol-Dexmedetomidine
- Registration Number
- NCT05674201
- Lead Sponsor
- Siirt Training and Research Hospital
- Brief Summary
In our study, the investigators aimed to compare the effects of dexmedetomidine-propofol and remifentanil-propofol combinations on perioperative spontaneous respiration, hemodynamics, recovery, participants, surgeon and anesthetist satisfaction in hysteroscopy, which is one of the ambulatory surgery.
- Detailed Description
This study was conducted prospectively after the approval of Van Yüzüncü Yıl University Ethics Committee. A total of 80 participants in 2 groups of 40 ASA I-II, aged 18-65 years were included in the study. On the day of the operation, vascular access was established with a 20 G branule in all patients before the procedure. The participants who were taken to the gynecology table were routinely monitored in the supine position as required by the procedure.
All participants were premedicated with 0.025 mg/kg Midazolam (Demizolam®, Dem, Turkey) after starting oxygen at 2 lt/min with a nasal cannula. The participants were randomly divided into two groups as Group DP and RP. Propofol (Propofol-®Lipuro 1%(10 mg/ml), B. Braun Indonesia ) 1mg/kg bolus was administered to both groups. Dexmedetomidine (Sedadomide 200 µg/2 ml, KOÇAK FARMA Turkey)
1mcg/kg bolus was administered to Group DP in 10 minutes, then 0.2-1.4 mcg/kg/hour infusion dose was started. After a 0.25mcg/kg bolus of Remifentanil (Ultiva®, GlaxoSmithKline, Belgium) was administered to Group RP, a 0.025-0.1mcg/kg/minute infusion dose was started.Hemodynamic data and respiratory parameters of the groups before and after sedation were recorded. The depth of anesthesia was recorded using the Ramsey sedation scale, and the recovery scores were recorded with the Modified Aldrete score. The facial pain scale was used to evaluate pain. Depth of anesthesia was provided so that the Ramsey Sedation Scale of the patients was greater than four. Patients with RSS\<4 were excluded from the study by administering additional propofol.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 2
AGE 18-65 ASA I AND II
- OTHERS
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Group RP Propofol-Dexmedetomidine Propofol (Propofol-®Lipuro 1%(10 mg/ml), B. Braun Indonesia ) 1mg/kg bolus was administered, After a 0.25mcg/kg bolus of Remifentanil (Ultiva®, GlaxoSmithKline, Belgium) was administered to Group RP, a 0.025-0.1mcg/kg/minute infusion dose was started. Group DP Propofol-Dexmedetomidine Propofol (Dexmedetomidine (Sedadomide 200 µg/2 ml, KOÇAK FARMA Turkey) 1mcg/kg bolus was administered to Group DP in 10 minutes, then 0.2-1.4 mcg/kg/hour infusion dose was started.-®Lipuro 1%(10 mg/ml), B. Braun Indonesia ) 1mg/kg bolus was administered.
- Primary Outcome Measures
Name Time Method SEDATİON through study completion, an average of 1 year RAMSEY SEDATİON SKORE \> 4 TİME (MİNUTE)
RECOVERY through study completion, an average of 1 year MODIFIED ALDRETE SCORE\>9 (MİNUTE)
END-TİDAL CO2 DURING THE SURGERY END-TİDAL CO2 (mmHg)
DESATURATION DESATURATION DURING THE SURGERY SATURATION SATURATION RATIOS (%)
RESPİRATORY RATE DURING THE SURGERY RESPİRATORY RATE (.../MİNUTE)
INTEGRATED PULMONARY INDEX DURING THE SURGERY INTEGRATED PULMONARY INDEX (1-10)
- Secondary Outcome Measures
Name Time Method NON INVASIVE SYSTOLİC AND BLOOD PRESSURE DURING THE SURGERY NON INVASIVE BLOOD PRESSURE ( mmHg)
HEART RATE DURING THE SURGERY HEART RATE (../MİNUTE)
NON INVASIVE DİASTOLİC BLOOD PRESSURE DURING THE SURGERY NON INVASIVE BLOOD PRESSURE ( mmHg)
Trial Locations
- Locations (1)
Siirt Eğitim Ve Araştirma Hastanesi
🇹🇷Siirt, Turkey