Clinical, Histological and Biochemical Characterization of Hyperpigmented Lesion.
试验速览
- 阶段
- 不适用
- 入组人数
- 160
- 试验地点
- 1
- 主要终点
- Characterization and classification of lentigines and melasma
研究概览
简要总结
Hypothesis -
The developments of solar lentigine and melasma are due to mutations in keratinocytes that drive the production and transfer of pigment from melanocytes to keratinocytes.
详细描述
Aims -
- Characterize and classify lentigines and mealsma from a clinical and physiological point of view. This will help us to better understand the cellular processes leading to the development of lentigines (also referred to as Senile or Solar Lentigo).
- Proper characterization and classification of lentigines and melasma would facilitate the development of models to study and find solutions to treat these lesions.
Hypothesis - The developments of solar lentigine and melasma are due to mutations in keratinocytes that drive the production and transfer of pigment from melanocytes to keratinocytes.
Methodology -
Patients, 21 - 80 year old, who have elected to undergo a plastic surgery will be enrolled. Some patient information (i.e. age, sex, race, family history, life-style related to sun-exposure) will be collected.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 21 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Solar Lentigines and/or Melasma on facial, or neck areas
- •Ethnic background: Chinese, Malay, Indian, Caucasian
- •Age 21 - 80 years old
- •Ability to provide informed consent
排除标准
- •Pregnant and lactating women
- •Children under the age of 20
- •Neoplasm (past or present) in excised area
- •Patients with communicable disease
- •Immuno-compromised patients
- •Current treatment with an investigational drug
结局指标
主要结局
Characterization and classification of lentigines and melasma
时间窗: 3 years
Characterize and classify lentigines and mealsma from a clinical and physiological point of view. This will better understand the cellular processes leading to the development of lentigines (also referred to as Senile or Solar Lentigo). Proper characterization and classification of lentigines and melasma would facilitate the development of models to study and find solutions to treat these lesions.
次要结局
未报告次要终点