Effects of Clonidine and Nifedipine on Hemodynamic Changes due to Laparoscopic Cholecystectomy

Phase 2

• Conditions: Cholecystitis.; Disorders of gallbladder and biliary tract in diseases classified elsewhere; k80-K87

• Registration Number: IRCT201305015471N1
• Lead Sponsor: Vice-Chancellor for Research of Qazvin University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1- Laparoscopic cholecystectomy
2- Age range between 20-60 years
3- ASA class I-II

Exclusion criteria
1- Positive history of systemic hypertension, congestive heart failure and aortic stenosis
2- Positive history of antihypertensive, narcotic and sedative drugs consumption
3- Patient refusal
4- Operation time more than 2 hours

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Blood pressure and heart rate after clonidine and nifedipine administration. Timepoint: Before induction of anesthesia, before surgical incision, before carbon dioxide insufflation and then every 5 minutes until the end of first hour of recovery period. Method of measurement: Noninvasive cardiovascular monitoring.

Secondary Outcome Measures

Name	Time	Method
Postoperative Pain. Timepoint: One hour after operation in recovery period and then for 24 hours in ward. Method of measurement: By Visual Analog Scale was determined and recorded in the questionnaire.;Shivering. Timepoint: One hour after operation in recovery period. Method of measurement: By observational method was determined and recorded in the questionnaire.;Nausea and vomiting. Timepoint: One hour after operation in recovery period. Method of measurement: By observational method was determined and recorded in the questionnaire.