ACTRN12608000053325
Recruiting
Phase 3
A multi-centre, randomised controlled trial of the effect of early goal-directed therapy, compared to standard care, on 90-day mortality in patients presenting to the Emergency Department with severe sepsis in Australasia
Australian and New Zealand Intensive Care Research Centre0 sites1,600 target enrollmentJanuary 29, 2008
Overview
- Phase
- Phase 3
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
- Enrollment
- 1600
- Status
- Recruiting
- Last Updated
- 6 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Suspected or confirmed infection
- •2\. 2 or more systemic inflammatory response syndrome (SIRS) criteria
- •3\. Evidence of either refractory hypertension or hypoperfusion
Exclusion Criteria
- •Contra\-indication to superior vena cava central venous catheter insertion; contra\-indication to blood products; inability to commence delivery of EGDT protocol within 1 hour of randomisation or complete 6 hours of EGDT; haemodynamic instability due to active bleeding; pregnancy; transfer from another ED or acute health care facility; the patient has an underlying disease process with a life expectancy of \< 90 days; death is deemed imminent and inevitable; a limitation of therapy order has been documented
Outcomes
Primary Outcomes
Not specified
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