Australasian Resuscitation In Sepsis Evaluation Randomised Controlled Trial

Phase 3

Recruiting

• Conditions: Severe sepsis; Infection - Studies of infection and infectious agents

• Registration Number: ACTRN12608000053325
• Lead Sponsor: Australian and New Zealand Intensive Care Research Centre

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2008-01-29
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 1600

Inclusion Criteria

1. Suspected or confirmed infection
2. 2 or more systemic inflammatory response syndrome (SIRS) criteria
3. Evidence of either refractory hypertension or hypoperfusion

Exclusion Criteria

Contra-indication to superior vena cava central venous catheter insertion; contra-indication to blood products; inability to commence delivery of EGDT protocol within 1 hour of randomisation or complete 6 hours of EGDT; haemodynamic instability due to active bleeding; pregnancy; transfer from another ED or acute health care facility; the patient has an underlying disease process with a life expectancy of < 90 days; death is deemed imminent and inevitable; a limitation of therapy order has been documented

Study & Design

• Study Type: Interventional
• Study Design: Not specified