Comparative Study of Antegrade Versus Retrograde Cerebral Perfusion in Acute Type a Aortic Dissection: a Prospective Study

Not Applicable

Completed

• Conditions: Acute Type a Aortic Dissection

• Registration Number: NCT06870513
• Lead Sponsor: Yusuf Shieba

Brief Summary

This prospective study investigated the comparison of effectiveness of antegrade cerebral perfusion (ACP) and retrograde cerebral perfusion (RCP) in providing cerebral protection during the surgical treatment of acute Type A aortic dissection (TAAD) Acute type A aortic dissection presents an aortic tear at its ascending portion, posing considerable risk with high morbidity and mortality incidence, especially from neurological insults.

In total, 48 patients of acute type A aortic dissection were randomly assigned to undergo surgical intervention with either ACP through axillary artery cannulation or RCP through superior vena cava cannula placed during deep hypothermic circulatory arrest. Primary objectives focused on measuring and comparing the postoperative neurological complication rates associated with transient neurological deficits (TND) and permanent neurological deficits (PND). Secondary outcomes of interest included the duration of mechanical ventilation, length of stay in the ICU and hospital, and mortality.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-06-22
• Primary Completion: 2023-01-01
• Study Completion: 2023-03-01
• Status Verified: 2025-03
• Study First Submitted: 2025-03-06
• Study First Submitted QC: 2025-03-06
• Last Update Submitted: 2025-03-06
• Study First Posted: 2025-03-11
• Last Update Posted: 2025-03-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

• Patients diagnosed with acute type A aortic dissection (TAAD).

Exclusion Criteria

• Hemodynamic instability.
• Known ischemic heart disease (IHD).
• History of cerebrovascular stroke.
• Heart failure.
• Renal or hepatic impairment.
• Rheumatic heart disease.
• Previous history of radiotherapy.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Incidence of Neurological Complications (Transient and Permanent Neurological Deficits)	Postoperative assessment period (up to 30 days after surgery)	Comparison of the incidence of neurological complications, including transient neurological deficits (temporary postoperative mental status changes or neurological dysfunction resolving within 24 hours) and permanent neurological deficits (lasting neurological impairments such as stroke, paralysis, coma, or death).

Secondary Outcome Measures

Name	Time	Method
Postoperative Mortality Rate	30 days post-surgery	Comparison of mortality rates within 30 days following surgical intervention between the two perfusion groups (ACP vs. RCP).

Trial Locations

Locations (1)

Department of Cardiothoracic Surgery, Faculty of Medicine, Suez Canal University.; 🇪🇬 Suez canal, Ismailia, Egypt