Stroke Volume Variation-guided Fluid Infusion in Major Liver Tumour Resection

Not Applicable

Completed

• Conditions: Fluid Management
• Interventions: Procedure: SVV-guided fluid management

• Registration Number: NCT05361252
• Lead Sponsor: Kaohsiung Veterans General Hospital.

Brief Summary

Studies have demonstrated that the rate of change in stroke volume variation (SVV) can be used to determine the volume of body fluids during major abdominal surgery. Anaesthesiologists can use SVV as a guide for the appropriate administration of intraoperative fluids to improve postoperative prognoses. Liver surgery is a major abdominal operation, and the amount of blood lost is typically higher than that during other general abdominal surgeries. Blood loss is positively correlated with the intraoperative fluid infusion volume, and greater blood loss is associated with more postoperative complications. Additionally, comorbid liver disease or cirrhosis can increase the complexity of liver tumour resection, causing difficulty in assessing intravascular volume and determining the appropriate intraoperative infusion volume.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-02-01
• Primary Completion: 2018-12-31
• Study Completion: 2018-12-31
• Study First Submitted: 2022-04-29
• Study First Submitted QC: 2022-04-29
• Study First Posted: 2022-05-04
• Status Verified: 2022-06
• Last Update Submitted: 2022-06-28
• Last Update Posted: 2022-07-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 118

Inclusion Criteria

• We initially selected 118 patients who required hepatectomy.
• The physiological status of the patients was assessed in terms of American Society of Anesthesiologists scores I-III

Exclusion Criteria

• Extreme body mass index (BMI)
• Age under 20 or over 75 years
• Emergency surgery
• Preexisting cardiac, hepatic, renal, or coagulation disorder; hyperthyroidism; and sinus arrhythmia.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
the high-SVV group	SVV-guided fluid management	the value of stroke volume variation will be higher than 10 this group
the low-SVV group	SVV-guided fluid management	the value of stroke volume variation will be less than or equal to 10 this group

Primary Outcome Measures

Name	Time	Method
The incidence of postoperative complications in the two groups.	From day 1 to day 30 after surgery.	calculate the incidence of postoperative complication within 30 days

Secondary Outcome Measures

Name	Time	Method
The differences of perioperative ALT	Examination report on the 1st postoperative day.	Calculate the difference of the perioperative physiological variables
The differences of perioperative T.bil	Examination report on the 1st postoperative day.	Calculate the difference of the perioperative physiological variables
The differences of perioperative arterial lactate	Examination report on the 1st postoperative day.	Calculate the difference of the perioperative physiological variables
The differences of perioperative albumin	Examination report on the 1st postoperative day.	Calculate the difference of the perioperative physiological variables
The differences of perioperative creatinine	Examination report on the 1st postoperative day.	Calculate the difference of the perioperative physiological variables
The differences of perioperative Hb	Examination report on the 1st postoperative day.	Calculate the difference of the perioperative physiological variables
The pain scale	up to three days postoperatively	Assessment of postoperative pain scale
The differences of perioperative eGFR	Examination report on the 1st postoperative day.	Calculate the difference of the perioperative physiological variables

Trial Locations

Locations (1)

Kaohsiung Veterans General Hospital; 🇨🇳 Kaohsiung, Taiwan