euronal correlates of post-stroke epilepsy and the associated cognitive impairment

Conditions: stroke, post-stroke epilepsy, cognitive deterioration.<br /> <br />Beroerte, epilepsie na beroerte, cognitieve achteruitgang.

Registration Number: NL-OMON23401

Lead Sponsor: Prof.Dr. Robert v Oostenbrugge, Department of Neurology, Maastricht University Medical Centre+ (MUMC+)

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 72

Inclusion Criteria

In order to be eligible to participate in this study, a subject must meet all of the following criteria:

- patients suffering from post-stroke epilepsy after cortical stroke defined as one or more unprovoked epileptic seizures occurring more than one week after the stroke, according to International League Against Epilepsy criteria(22), with the onset of clinical stroke symptoms less 2 years prior to inclusion.

Exclusion Criteria

A potential subject (PSE or control) who meets any of the following criteria will be excluded from participation in this study:

-primary intracerebral hemorrhage

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
- BBB permeability as determined by DCE-MRI to assess the leakiness of the cerebral vasculature by dynamically measuring the rate of contrast agent transfer from blood into the interstitial space (leakage rate; units: mL / (min 100 g tissue)). We will compare BBB permeability in PSE patients with non-PSE.<br /><br>- Resting state functional MRI: connectivity measures, locally as well as whole brain network analysis (using graph theoretical measures) as well as DTI connectivity measures, locally (mean diffusivity/fractional anisotropy) and anatomical features (measured by standard T2, SWI and FLAIR sequences: gliosis, iron deposits microbleeds, dilated perivascular spaces, and cortical and subcortical ischemic lesions).<br>

Secondary Outcome Measures

Name	Time	Method
- Stroke and post-stroke epilepsy outcome will be assessed using the NIHSS.<br /><br>-All patients and healthy controls will undergo cognitive testing, focussed on assessing central processing speed using the CVST (Grevers et al., 2016 ). In addition the highest premorbid educational level will be determined . Laesional deficits (such as dysphasia) will be tested at inclusion. <br>