The Genetic Basis for Vulnerability to Substance Abuse

Completed

• Conditions: Substance Abuse

• Registration Number: NCT00247819
• Lead Sponsor: National Institute on Drug Abuse (NIDA)

Brief Summary

This investigation seeks to better define the genetic basis for vulnerability to substance abuse.

Detailed Description

Dopamine (DA), a neurotransmitter helping to mediate reward and reinforcement, has been putatively linked to the development of substance abuse, alcohol abuse, and alcoholism. Identification of specific vulnerability-association alleles for receptors, other molecules within the reward mediating system, and other genes that may predispose individuals to the development of such disorders is the goal of the study.

This investigation will help elucidate the genetic underpinnings of substance abuse, potentially leading to the improved methods to diagnose those at risk and to help develop better therapeutic interventions.

Study Timeline

• Study Start: 1992-08
• Status Verified: 2005-10
• Study First Submitted: 2005-10-31
• Study First Submitted QC: 2005-10-31
• Study First Posted: 2005-11-02
• Primary Completion: 2006-02
• Study Completion: 2006-02
• Last Update Submitted: 2017-01-11
• Last Update Posted: 2017-01-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 8000

Inclusion Criteria

• Substance abusers
• Allow for blood draw

Exclusion Criteria

• Cognitively impaired

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

National Institute on Drug Abuse; 🇺🇸 Baltimore, Maryland, United States