2025-520808-10-00招募中3 期
Role of inhaled nitric oxide on right ventricular function and pulmonary vascular mechanics following cardiac surgery
Fundacion Para La Investigacion Biomedica Del Hospital Universitario La Princesa2 个研究点 分布在 1 个国家目标入组 50 人开始时间: 2025年1月24日最近更新:
试验速览
- 阶段
- 3 期
- 状态
- 招募中
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Parameters of right ventricular function
研究概览
简要总结
To study the effects of inhaled iNO on pulmonary vascular mechanics, right ventricular function, and right ventricular-vascular coupling in patients in the immediate cardiac surgery post-operative period
入排标准
- 年龄范围
- 18 years 至 65+ years（65+ Years, 18-64 Years）
- 接受健康志愿者
- 否
入选标准
- •Obtained informed consent
- •Age > 18 years
- •Under passive mechanical ventilation
- •Pre-operative FEVI ≥ 30%
- •Absence of hypovolemia: absence of ventricular "kissing" and / or superior vena cava collapsibility index < 20%
- •Stable spontaneous heart rythm
- •Post-operative hemodynamic stability
排除标准
- •Cor pulmonale or presence of preoperative pulmonary vascular pathology
- •Chronic pulmonary hypertension (mPAP> 35 mmHg) related to advanced COPD or chronic thromboembolic disease
- •Surgery involving the tricuspid or pulmonary valves
- •Intra- or post-operative use of nitroprusside or nitroglycerine
- •Pre-operative dependence of inotropic drugs or vasoconstrictors
- •Use of levosimendan. If dobutamine is in use, patients can be included provided the infusion can be stopped or is ≤ 1 µg/kg/min
- •Pacemaker dependency
结局指标
主要结局
Parameters of right ventricular function
Parameters of right ventricular function
次要结局
- Results of the electrical impedance tomography (EIT): regional distribution of ventilation and perfusion and EIT pulsatility
研究者
Isabel Magaña Bru
Scientific
Fundacion Para La Investigacion Biomedica Del Hospital Universitario La Princesa
研究点 (2)
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