Capsaicin in digital osteoarthritis versus control : a randomized study - PHRC IR 2022 MATHIE

niversity Hospital Of Clermont-Ferrand0 个研究点目标入组 120 人开始时间: 2024年2月7日最近更新: 2024年7月22日

适应症

试验速览

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•age greater than or equal to 18 years, diagnosis of digital osteoarthritis according to the criteria of the American College of Rheumatology, presence of finger pain of intensity = 40 mm on a VAS;, presence of finger pain with a neuropathic painful component (DN4 score = 4/10, inadequate response, adverse effects and/or contraindication to traditional analgesics and NSAIDs;, able to read and understand study information, signed informed consent, affiliation to a social security scheme., Women of childbearing age must use effective contraception (pill, contraceptive implant, IUD, condoms or tubal ligation) for the entire duration of the trial

•patient with isolated rhizarthrosis, patient with fibromyalgia according to the opinion of the investigating doctor;, pregnant or breastfeeding woman; (a urine pregnancy test will be carried out in women of childbearing age before any transdermal patch placement), patient under guardianship or curatorship or deprived of liberty., patient with another joint disease affecting the fingers (gout, chondrocalcinosis, RA, spondyloarthritis, psoriatic arthritis); ? patient with upper limb pain syndrome which could interfere with the assessment of finger pain, patient with another pathology responsible for neuropathic hand pain (carpal tunnel syndrome, diabetic neuropathy, Guyon's canal syndrome, cervico-brachial neuralgia, brachial plexitis), patient with skin lesions on the fingers (psoriasis, wounds, chronic ulcers, eczema, shingles, dermatitis), patient with poorly controlled arterial hypertension, patient with hypersensitivity to capsaicin, patient having had an 8% capsaicin patch applied in the year before the study, patient having received intramuscular, intra-articular or intravenous corticosteroid therapy, another basic anti-rheumatic treatment (methotrexate, salazopyrine) or an intra-articular injection into the finger joints in the previous three months, patient wearing wrist or finger orthoses in the previous month

发起方

niversity Hospital Of Clermont-Ferrand