NCT00345215已完成不适用
The Effect of High and Low Sodium Intake on Aquaporin-2 in Healthy Humans, During Basal Conditions and After Hypertonic Saline Infusion.
Regional Hospital Holstebro2 个研究点 分布在 1 个国家目标入组 26 人开始时间: 2006年5月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 26
- 试验地点
- 2
- 主要终点
- u-AQP-2
研究概览
简要总结
The aim of the study is to test the hypothesis that the function and/or regulation of aquaporin 2 and/or endothelial sodium channels in the principal cells of healthy humans is abnormal at high and low sodium intake
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Caucasic men and women
- •Age 18-65 years
- •Body mass index less or equal to 30 Kg/m2
排除标准
- •Arterial hypertension
- •History or clinical signs of heart, brain, lung, kidney, malignant or endocrine organ disease.
- •Abnormal biochemical screening of the blood regarding: red and white cell count, B-hemoglobin, P-sodium, P-potassium, P-creatinine, P-albumine, P- bilirubin, P-alanine aminotransferase, P- alkaline phosphatase, p-cholesterol and B-glucose.
- •Abnormal screening of the urine regarding: blood, albumine and glucose.
- •Alcohol or drug abuse
- •Drug use except oral contraceptives
- •Abnormal electrocardiogram
- •Blood donation within one month of the first examination day
- •Pregnancy
- •Unwillingness to participate
结局指标
主要结局
u-AQP-2
时间窗: Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively.
fractional sodium excretion
时间窗: Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively.
p-aldosterone
时间窗: Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively.
次要结局
- u-pAQP-2(Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively.)
- u-ENaC(alfa-beta-gamma)(Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively.)
- CH20(Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively.)
- ucAMP(Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively.)
- uPGE2(Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively.)
- GFR(Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively.)
研究者
研究点 (2)
Loading locations...
相似试验
已完成
不适用
The Effect of High and Low Sodium Intake on Urinary Aquaporin-2 in Autosomal Dominant Polycystic Kidney DiseasePolycystic Kidney, Autosomal DominantNCT00410007Carolina Cannillo29
已完成
不适用
The Effect of High and Low Sodium Intake on Urinary Aquaporin-2 in Essential HypertensionEssential Hypertension and Healthy ControlsNCT00345124Regional Hospital Holstebro50
已完成
不适用
Hemodynamics, Salt Sensitivity and Body Composition in Patients With Morbid ObesityHypertensionObesityNCT00998465Zealand University Hospital36
已完成
不适用
Salt Intake, Hydration Status and Gastrointestinal Discomfort During FastingHealthyNCT05839860Oxford Brookes University23
招募中
不适用
Investigation on the effect of sodium intake and anti-hypertensive therapy in the treatment HypertensioHypertensionJPRN-UMIN000005916Department of Cardiovascular Medicine100