Evaluation of Serum Amyloid A in Early Diagnosis of Spontaneous Bacterial Peritonitis
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Number of patients with elevated serum amyloid A
研究概览
简要总结
One of the most common and serious complications in decompensated cirrhotic patients (DCPs) is bacterial infection.The most common infections in DCPs are cases of spontaneous bacterial peritonitis (SBP), which account for 40% 70% of cases, followed by urinary tract infections, pneumonia and cellulitis.
Serum amyloid A (SAA) and C-reactive protein (CRP) are acute-phase proteins predominantly produced and secreted by hepatocytes. Other cells including lymphocytes, monocytes, and macrophages can also produce these proteins. The induction of SAA and CRP synthesis is triggered by a number of cytokines, chiefly IL-6, which is released from a variety of cell types, but mainly from macrophages and monocytes at inflammatory sites
详细描述
Increased serum CRP and SAA levels have been found in a number of disorders, including bacterial infections, malignancies tissue injuries and tissue rejection. Therefore, new studies of early diagnosis, prevention and treatment are needed to improve clinical outcomes.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •• Decompansated cirrhosis with ascites, defined by a combination of any of the following:
- •Laboratory findings
- •Endoscopic results
- •Ultrasound
- •Histology
排除标准
- •Creatinine>1.5 mg/dl
- •Other infection e.grespiratory,UTI ,gastrointestinal and skin infection.
- •Hepatocellular carcinoma
- •Other extrahepatic malignancy e.g ; chest
- •Any significant psychiatric illness or other medical comorbidity.
- •Any degenerative diseases.
结局指标
主要结局
Number of patients with elevated serum amyloid A
时间窗: 6months
次要结局
未报告次要终点
研究者
Sherief Abd-Elsalam
Consultant liver and GIT diseases- Tanta university hospital
Tanta University