Liver X Receptor (LXR) as a Novel Therapeutic Target in Diabetic Retinopathy (DR)
- Conditions
- Diabetic Retinopathy
- Registration Number
- NCT03403686
- Lead Sponsor
- University of Alabama at Birmingham
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria:<br><br> - Any man or woman between the ages of 21- 98 years of age will be eligible to<br> participate. To participate in the study as a study subject we will require: a) the<br> subject must either carry the diagnosis of diabetes or be a healthy aged control and<br> b) the patient be willing and have the ability to cooperate with the protocol.<br><br>Exclusion Criteria:<br><br> - Exclusion criteria: We will apply the following exclusion criteria: a) evidence of<br> ongoing acute or chronic infection (HIV, Hepatitis B or C, tuberculosis); b) ongoing<br> malignancy; c) cerebral vascular accident or cerebral vascular procedure; d) current<br> pregnancy; e) history of organ transplantation; f) presence of a graft (to avoid any<br> effect of the graft on inflammatory parameters; g) uremic symptoms, an estimated<br> glomerular filtration rate of less than 20 cc/min (by Modification of Diet in Renal<br> Disease equation), or an albumin of less than 3.6 (to avoid malnutrition as a<br> confounding variable); h) be unwilling to abstain from drinking alcohol and i)<br> patients with anemia. Subjects with AMD, glaucoma, uveitis, known hereditary<br> degenerations or other significant ocular complications other than diabetic<br> retinopathy will be excluded.
Not provided
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Assessing CD34+ cells function
- Secondary Outcome Measures
Name Time Method