Assessment of Vitamin B12 Bioavailability From Egg
- Conditions
- Bioavailability of Vitamin B12 From Chicken Eggs
- Registration Number
- NCT01366937
- Lead Sponsor
- USDA, Western Human Nutrition Research Center
- Brief Summary
The hypothesis of this study is that chicken eggs can be enriched in vivo with 14C-B12 and fed to healthy human subjects to determine B12 bioavailability from eggs.
The goal of this research is to enrich eggs in vivo with radioactively labeled vitamin B12 to a level that allows us to feed the enriched eggs to humans and determine how much of the vitamin B12 is digested and absorbed into the body. This will tell us if eggs are a good dietary source of vitamin B12. Importantly, sensitive technology available at the Lawrence Livermore National Laboratories allows us to measure very low amounts of radioactive vitamin B12. This allows us to do this experiment with a level of radioactive B12 that is not harmful to animals or humans. The results of the investigators first experiment indicate that the investigators can inject radioactively labeled vitamin B12 into a laying hen and detect the radioactive vitamin B12 in the eggs at a level sufficient for feeding to humans in a bioavailability study.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 10
- normal healthy subjects, adequate B12 status and absorptive capacity and the availability to complete the protocol.
- any chronic health disorder, anemia of any kind, renal insufficiency, and pregnancy or lactation.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Fecal enrichment of 14C Over the course of 8 days after dosing with 14C labeled egg
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Usda, Ars, Whnrc
🇺🇸Davis, California, United States