The Relationship Between Zonulin and Interleukin-8 Levels and Postoperative Delirium Development in Patients Who Had Femur Fracture Surgery Under Regional Anesthesia
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 73
- Locations
- 1
- Primary Endpoint
- postoperative Zonulin
Study Overview
Brief Summary
The relationship between zonulin and interleukin-8 levels and postoperative delirium development in patients who had femur fracture surgery under regional anesthesia
Detailed Description
Patients who are over 65 years of age and scheduled for femur fixation surgery will be included in the study. Blood samples for zonulin and interleukin-8 levels will be taken at the day prior to the surgery. All patients will be evaluated by the Turkish version of the Delirium Rating Scale-Revised-98 (DRS-R-98) for delirium development at the postoperative 1., 2. and 3. days. Patients with a DRS-R-98 score of 11 points or higher will be included in the Group Delirium. And second blood samples for zonulin and interleukin-8 levels will be taken at the time of diagnosis.
Postoperative pain scores of the patients will recorded by using a numerical rating scale (NRS).
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 65 Years to — (Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •patients over 65 years with mini mental state score > 21, undergoing femur fixation surgery
Exclusion Criteria
- •anticholinergic drug use, known epilepsy, Parkinson, Alzheimer's disease, dementia, cognitive function disorder
Outcomes
Primary Outcomes
postoperative Zonulin
Time Frame: At the postoperative 72. hour
The relation between postoperative delirium development and postoperative blood zonulin levels The correlation between them will be analyzed by statistical analysis.
preoperative Zonulin
Time Frame: in the preoperative 24. hour
The relation between postoperative delirium development and preoperative blood zonulin levels. The correlation between them will be analyzed by statistical analysis.
Secondary Outcomes
- postoperative Interleukin-8(At the postoperative 72. hour)
- preoperative Interleukin-8(in the preoperative 24. hour)
Investigators
Dr. Gokhan Vural
Anesthesiologist Dr. Gokhan
Muğla Sıtkı Koçman University