A Phase I, Open-label, Dose-Finding Study to Assess the Safety and Tolerability of U3-1287 (AMG 888), a Human Monoclonal Antibody Targeting HER3 in Patients With Advanced Solid Tumors.

U3 Pharma GmbH6 sites in 1 country60 target enrollmentAugust 2008

ConditionsAdvanced Solid Tumors

InterventionsU3-1287 (AMG888)

DrugsU3-1287 (AMG888)

Overview

Phase: Phase 1
Intervention: U3-1287 (AMG888)
Conditions: Advanced Solid Tumors
Sponsor: U3 Pharma GmbH
Enrollment: 60
Locations: 6
Primary Endpoint: To evaluate the safety and tolerability of U3-1287 (AMG888) in patients with advanced solid tumors
Status: Completed
Last Updated: 15 years ago

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Sites Similar Trials

Overview

Brief Summary

This is a Phase 1 clinical study to investigate the safety, pharmacokinetics, and pharmacodynamics of U3-1287 (AMG 888), a fully human monoclonal antibody targeting the HER3 receptor, in patients with advanced solid tumors. Eligible patients will have disease that is refractory or resistant to standard treatments or for which no standard therapy exists. The study will be conducted in two parts; a dose escalation (Part 1) and a dose expansion (Part 2). The hypothesis for this study is that U3-1287 (AMG888) will be safe and well tolerated in patients with advanced solid tumors and will show initial evidence of anti-tumor activity.

Registry

clinicaltrials.gov

Start Date

August 2008

End Date

July 2010

Last Updated

15 years ago

Study Type

Interventional

Study Design

Single Group

Sex

All

Investigators

Sponsor

U3 Pharma GmbH

Eligibility Criteria

Inclusion Criteria

•Pathologically or cytologically documented advanced solid tumor that is refractory to standard treatment, for which no standard therapy is available, or the patient refuses standard therapy.
•Eastern Cooperative Oncology Group (ECOG) performance status ≤
•Men or women at least 18 years of age
•Adequate hematologic, cardiac, renal, hepatic, metabolic, and coagulation function

Exclusion Criteria

•Presence of untreated or symptomatic brain metastasis.
•Presence of ascites or pleural effusion requiring chronic medical intervention.
•Uncontrolled hypertension
•Concurrent or previous (within 1 week of study day 1) anticoagulation therapy, except low-dose warfarin (≤ 2 mg/day) or low dose,low molecular weight heparin for prophylaxis against central venous catheter thrombosis.
•Recent major surgical procedure or not yet recovered from major surgery
•Recent participation in clinical drug trials.
•Participation in other investigational procedures.
•Unresolved toxicities from prior anti-cancer therapy
•Patient who is pregnant (e.g. positive human choriogonadotropin \[HCG\] test) or nursing.