The effect of pulmonary rehabilitation in COPD: Dynamic hyperinflation and systemic inflammation during daily activities.
- Conditions
- COPD
- Registration Number
- NL-OMON27345
- Lead Sponsor
- Radboud University Nijmegen Medical Centre, Department of Pulmonary diseases
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 26
Inclusion Criteria
1. Stable COPD GOLD I-III;
2. Dynamic hyperinflation during ADL.
Exclusion Criteria
1. Long term oxygen therapy at home;
2. Severe ADL-limiting cardiac or neuromuscular disease;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Dynamic hyperinflation;<br /><br>2. Dyspnea;<br /><br>3. Biomarkers of systemic inflammation after ADL.<br><br /><br /><br>Dynamic hyperinflation and other respiratory impairments during ADL will be measured using the Oxycon Mobile (Viasys Healthcare, Germany), which is a portable breath-by-breath system, consisting of a face mask with turbine volume transducer and integrated O2 and CO2 gas analyzers. Subjects will be asked to rate their shortness of breath using a 10-point Borg scale at start and end of each ADL. Systemic inflammation will be characterized by measuring the number of circulating leukocytes (standard laboratory tests), and plasma levels of interleukins.
- Secondary Outcome Measures
Name Time Method