International Survey of Acute Coronary Syndromes

Recruiting

• Conditions: Unstable Angina Pectoris; Coronary Disease; Acute Coronary Syndrome; Myocardial Infarction

• Registration Number: NCT01218776
• Lead Sponsor: University of Bologna

Brief Summary

The International Registry of Acute Coronary Syndromes registry study (ISACS) is both a retrospective and prospective study which was designed in order to obtain data of patients with acute coronary syndromes, and herewith control and optimize internationally guideline-recommended therapies in these countries

Detailed Description

Aims of this survey study are (1) documentation of the characteristics of all patients presenting to the ISACS centers with STEMI or NSTEMI (2) documentation of in-hospital outcome, and outcome rates at 6 month and 1 year, (3) documentation of invasive procedures and procedure-associated complications (4) documentation of therapeutic regimens and investigation conformity of treatment with already established guidelines.

Investigators:

ISACS Administrative Committee:

Raffaele Bugiardini (Italy-Principal Investigator) Lina Badimon (Spain) Olivia Manfrini (Italy- Project Coordinator) Edina Cenko (Italy-Center Coordinator)

Steering Committee:

Mirza Dilic (Bosnia and Herzegovina), Asen Goudev (Bulgaria), Davor Milicic (Croatia), Raffaele Bugiardini, Edina Cenko and Olivia Manfrini (Italy) Gani Bajraktari (Kosovo), Andrejs Erglis and Ilja Zakke (Latvia), Remigius Zaliunas and Olivija Gustiene (Lithuania), Sasko Kedev and Marija Vavlukis (North Macedonia), Mihail Popovici (Moldova), Maria Dorobantu (Romania), Zorana Vasiljevic (Serbia), Eva Goncalvesova and Martin Studenkan (Slovakia) , Alexander N. Parkhomenko (Ukraine) , Christopher P Gale (United Kingdom).

Study Timeline

• Study Start: 2010-09-28
• Study First Submitted: 2010-10-07
• Study First Submitted QC: 2010-10-08
• Study First Posted: 2010-10-11
• Status Verified: 2025-04
• Last Update Submitted: 2025-04-11
• Last Update Posted: 2025-04-16
• Primary Completion: 2026-12-31
• Study Completion: 2026-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 36000

Inclusion Criteria

• acute coronary syndromes

Exclusion Criteria

• under age or not able to give informed consent

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
All causes mortality	30 days, 6 months, 1 year	All causes mortality

Secondary Outcome Measures

Name	Time	Method
Cardiovascular mortality	30 days, 6 months, 1 year	Cardiovascular mortality
Adherence to internationally guideline recommended therapies across the participating countries	discharge, 6 months, 1 year	Adherence to internationally guideline recommended therapies across the participating
Recurrent myocardial infarction	30 days, 6 months, 1year	Recurrent myocardial infarction
Pharmacogenetic and cardiovascular genetic studies associated to clinical outcomes	6 month, 1 year	Pharmacogenetic and cardiovascular genetic studies associated to clinical outcomes

Trial Locations

Locations (1)

University of Bologna; 🇮🇹 Bologna, Emilia Romagna, Italy