NCT04552977Unknown2 期
A Trail of Fluzoparil in Combination With Temozolomide in Patients With Recurrent Glioblastoma
Shandong Cancer Hospital and Institute0 个研究点目标入组 50 人开始时间: 2020年9月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 2 期
- 发起方
- 入组人数
- 50
- 主要终点
- 6-months PFS rate in all participants by RECIST 1.1
研究概览
简要总结
This is a one arm, open, single center phase II study. The main purpose of this study was to evaluate the efficacy and safety of fluzoparil combined with temozolomide in patients with recurrent glioblastoma.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Voluntary participation and written informed consent;
- •The age was 18-70 years old, with no gender limit;
- •Supratentorial space occupying lesions were diagnosed as glioblastoma by pathology;
- •Patients received standard radiotherapy and temozolomide concurrent chemotherapy after surgery, and the interval between the last radiotherapy and the last radiotherapy was ≥ 4 weeks (pseudo progression should be excluded);
- •MRI confirmed that the tumor had definite recurrence. The diameter of the enhancement focus was more than 1 cm and more than 2 layers (layer spacing was 5 mm), or the recurrence was confirmed by pathology after re biopsy or operation;
- •The recurrence site or other reasons can not be resected;
- •The methylation status of MGMT promoter had been detected or was willing to be detected before enrollment;
- •According to recist1.1, there was at least one measurable lesion;
- •KPS score ≥ 60 points;
- •The tablets can be swallowed normally;
- •The expected survival time was more than 3 months;
- •Sufficient organs and bone marrow function. The definition is as follows.
- •Neutrophil count (ANC) ≥ 1500 / mm3 (1.5 ×109 / L);
- •Platelet count (PLT) ≥ 100000 / mm3 (100 × 109 / L);
- •Hemoglobin (HB) ≥ 9 g / dl (90 g / L);
- •Serum albumin ≥ 2.8 g / dl;
- •Serum creatinine ≤ 1.5 times the upper limit of normal value (ULN) or creatinine clearance rate ≥ 60 ml / min;
- •Total bilirubin (TB) ≤ 1.5 × ULN, or total bilirubin (TB) > 1.5 × ULN, but direct bilirubin (DBIL) ≤ 1 × ULN; patients with liver metastasis should be ≤ 2 × ULN;
- •The level of AST / SGOT or ALT / SGPT should be ≤ 2.5 × ULN and ≤ 5 × ULN in patients with liver metastasis;
- •Left ventricular ejection fraction (LVEF) ≥ 50%, QTc < 450 ms in male and < 470ms in female;
- •The international normalized ratio (INR) of prothrombin time was ≤1.5 and activated partial thromboplastin time (APTT) were ≤1.5 times the upper limit of normal value in patients who had not received anticoagulant therapy. Patients receiving full dose or parenteral anticoagulant therapy can enter the clinical trial as long as the dosage of anticoagulant drugs is stable for at least 2 weeks before entering the clinical study, and the results of coagulation test are within the limits of local treatment;
- •Women of childbearing age should have negative pregnancy test (serum or urine) within 7 days before enrollment, and voluntarily use appropriate contraceptive methods during the observation period and within 8 weeks after the last administration of the study drug; for men, it should be surgical sterilization or agree to use appropriate contraceptive methods during the observation period and within 8 weeks after the last administration of the study drug;
- •Good compliance, can cooperate with the study and follow-up according to the requirements of the program.
排除标准
- •Patients had been treated with PARP inhibitors in the past;
- •Previous allergic history of temozolomide or fluzoparide, previous allergy to dacarbazine, and allergic reaction to temozolomide or fluzoparide;
- •Patients had inherited galactose intolerance, lactase deficiency and glucose galactose malabsorption;
- •The following treatments or drugs were received before the first study treatment:
- •Major surgery (biopsy is allowed due to diagnosis) or severe trauma within 4 weeks before the first use of the study drug;
- •Received strong CYP3A4 inducer or inhibitor within 2 weeks after the first use of the study drug;
- •Previously vaccinated with anti-tumor vaccine; vaccinated with live attenuated vaccine within 28 days before the first study drug treatment or within 60 days after the end of study drug treatment;
- •Currently participating in other clinical studies, unless it is an observational (non intervention) clinical study or an intervention in the follow-up of a new clinical study; or has participated in any other drug clinical study within 4 weeks before the first administration, or no more than 5 half-life from the last study medication;
- •Except basal cell carcinoma or squamous cell carcinoma of skin, superficial bladder cancer, carcinoma in situ of cervix, intraductal carcinoma in situ of breast and papillary thyroid carcinoma which can be treated locally and have been cured in the past 5 years or at the same time;
- •Advanced patients with symptoms, spread to the viscera, and at risk of life-threatening complications in a short period of time (including patients with uncontrollable large amount of exudate [chest, pericardium, abdominal cavity];
- •Fever of unknown origin > 38.5℃ occurred during the screening period / before the first administration (according to the researcher's judgment, fever caused by tumor can be included in the group);
- •Severe infection (CTCAE > Level 2) occurred within 4 weeks before the first use of the study drug, such as severe pneumonia, bacteremia, infection complications, etc. the baseline chest imaging examination revealed active pulmonary inflammation, symptoms and signs of infection within 2 weeks before the first use of the study drug, or the need for oral or intravenous antibiotic treatment (excluding prophylactic use of antibiotics)；
- •Within 6 months before entering the study, the following conditions occurred: myocardial infarction, severe / unstable angina pectoris, NYHA grade 2 or above cardiac insufficiency and clinically significant supraventricular or ventricular arrhythmias requiring clinical intervention; hypertension with poor drug control (systolic blood pressure continuously increased ≥ 150mmhg or diastolic blood pressure ≥ 100mmhg);
- •History of gastrointestinal bleeding or tendency of gastrointestinal bleeding in the past 6 months, such as esophageal varices, local active ulcer lesions, fecal occult blood≥(+) (gastroscopy is required when fecal occult blood is (+));
- •Unable to swallow the study drug, chronic diarrhea (including but not limited to irritable bowel syndrome, Crohn's disease, ulcerative colitis), intestinal obstruction and other factors affecting drug administration and absorption;
- •Urine protein ≥ + + + or 24-hour urine protein > 1.0g;
- •History of allogeneic organ transplantation or allogeneic hematopoietic stem cell transplantation or congenital immunodeficiency was known;
- •Patients with active pulmonary tuberculosis infection found through medical history or CT examination, or patients with active pulmonary tuberculosis infection within one year before enrollment, or patients with active pulmonary tuberculosis infection history one year ago but without regular treatment;
- •Human immunodeficiency virus (HIV) infection or acquired immunodeficiency syndrome (AIDS); untreated active hepatitis B (hepatitis B, defined as hepatitis B virus surface antigen [HBsAg] positive test results, HBV-DNA ≥ 500 Hepatitis C was defined as hepatitis C antibody [HCV AB] positive, HCV-RNA higher than the detection limit of analysis method and abnormal liver function), or combined with hepatitis B and hepatitis C co infection;
- •Patients had a clear history of neurological or mental disorders, including epilepsy and dementia, and was known to have a history of psychotropic substance abuse, alcoholism or drug abuse;
- •Patients who were considered unsuitable for the study.
研究组 & 干预措施
fluzoparil+temozolomide
Experimental
Participants receive fluzoparil and temozolomide
干预措施: fluzoparil (Drug)
fluzoparil+temozolomide
Experimental
Participants receive fluzoparil and temozolomide
干预措施: temozolomide (Drug)
结局指标
主要结局
6-months PFS rate in all participants by RECIST 1.1
时间窗: Up to approximately 24 months
6-months progression-free survival rate in all participants by RECIST 1.1
次要结局
- Overall survival (OS) in all participants(Up to approximately 24 months)
- Number of participants experiencing a serious adverse event (SAE)(From first dose to last dose of treatment plus 2 months of follow-up, up to 24 months)
- mOS in all participants(Up to approximately 24 months)
- Disease control rate in all patients by RECIST Version 1.1(Up to approximately 24 months)
- mPFS in all participants(Up to approximately 24 months)
- Number of participants experiencing an adverse event (AE)(From first dose to last dose of treatment plus 2 months of follow-up, up to 24 months)
- ORR in all paients by RECIST Version 1.1(Up to approximately 24 months)
研究者
Jinming Yu
President of Shandong Cancer Hospital and Institute
Shandong Cancer Hospital and Institute
相似试验
已完成
1 期
Phase 1-2 of Temozolomide and Hypofractionated Radiotherapy in Tx of Supratentorial Glioblastoma MultiformCancer of Brain and Nervous SystemGlioblastomaGlioblastoma MultiformeNCT01120639Stanford University30
终止
2 期
Phase II Study of Combined Temozolomide and SGT-53 for Treatment of Recurrent GlioblastomaRECURRENT GLIOBLASTOMANCT02340156SynerGene Therapeutics, Inc.1
进行中（未招募）
2 期
Temozolomide With or Without Veliparib in Treating Patients With Relapsed or Refractory Small Cell Lung CancerNCT01638546National Cancer Institute (NCI)97
已完成
2 期
Randomized Phase II Trial of Letrozole With or Without Dasatinib as First and Second-line Treatment for Hormone Receptor-positive, HER2-negative Post-menopausal Breast Cancer That is Unresectable, Locally Recurrent or MetastaticMetastatic Breast CancerNCT00696072Bristol-Myers Squibb120
进行中（未招募）
2 期
Talazoparib and Low-Dose Temozolomide in Treating Participants With Relapsed or Refractory Extensive-Stage Small Cell Lung CancerRecurrent Extensive Stage Small Cell Lung CarcinomaRefractory Extensive Stage Small Cell Lung CarcinomaNCT03672773Jonsson Comprehensive Cancer Center35