The clinical effect of pregabalin on neuropathic pain in central sensitized patients who are treated with duloxetine after total knee arthroplasty: Randomized Controlled Trial
- Conditions
- Diseases of the musculoskeletal system and connective tissue
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 90
? Patients for total knee arthroplasty over the age of 19.
? Patients who have the will or ability to follow the doctor's instructions, including rehabilitation treatment such as joint exercise.
? Patients understand this study and agree in writing by the patient's own or by the patient's representative to participate in the study.
? Patients with central sensitization and neuropathic pain.
? Local infection, sepsis, or neurological abnormalities in the lower extremities of the surgical site.
? Patients with inflammatory arthritis or crystalline sedimentary arthritis.
? Patients who are hypersensitive to duloxetin or prevalin sanctions or show excessive complications.
? Patients who received treatment for anemia within a month of surgery.
? Patients with uncontrolled hypertension with relaxed blood pressure of 100mmHg or more
? Patients with abnormal liver function (aspartate aminotransferase or alanine aminotransferase >60 IU litre)
? Patients who can't do rehabilitation alone or need assistance.
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Visual Pain Scale
- Secondary Outcome Measures
Name Time Method Western Ontario and McMaster University Arthritis Index (WOMAC) Scale;Knee range of motion