Asthma and obstructive sleep apnea

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 42

Inclusion Criteria

1. Control group:
1.1. Normal males or females, who are 18 years or older.
1.2. No asthma on spirometry and no bronchodilator reversibility.
1.3. No OSA on sleep study and
1.4. No other known significant clinical condition according to the clinical assessment of Dr West/Dr Burns
2. OSA group:
2.1. Males or females, who are 18 years or older.
2.2. Significant OSA on sleep study,
2.3. having empirical CPAP clinically,
2.4. no asthma on spirometry and no bronchodilator reversibility.
2.5. No other known significant clinical condition according to the clinical assessment of Dr. West/Dr. Burns
3. Asthma group:
3.1. Males or females, who are 18 years or older who have a hospital corroborated clinical diagnosis of asthma.
4. Asthma with OSA group:
4.1. Males or females, who are 18 years or older
4.2. Confirmed asthma and confirmed OSA

Definitions:
1. No asthma” means: no history of asthma, normal spirometry and no bronchodilator response
2. Asthma” means: hospital specialist respiratory physician diagnosis, with history consistent with asthma, previous obstructive spirometry, ratio <70%, minimal smoking history or normal TLCO, (± bronchodilator response if documented previously) without evidence of chronic obstructive pulmonary disease (COPD) i.e. normal gas transfer
3. Significant OSA” means: oxygen desaturation index of >10 per hour or AHI of >15 per hour on overnight sleep study

Exclusion Criteria

For all groups
1. Inability to give written informed consent in English.
2. Where a participant is already involved in other research studies or medical intervention, which might have contraindications for this study.
3. Patients regarded unfit for any other clinical reason by their respiratory or sleep physician
4. As the study involve the use of a Pulmonary Function Test (PFT), some individuals with certain conditions should not take a PFT, as it can cause problems. These conditions include:
4.1. Recent heart attack
4.2. Heart disease
4.3.Recent eye surgery
4.4.Recent chest or abdominal surgery
4.5.Respiratory infections

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> 1. The number of patients who were eligible for the study<br> 2. The number invited to take part in the study<br> 3. The number that entered the study<br> 4. The number that completed the study<br> 5. The number of patients where all observations were obtained<br><br> This information is obtained and updated at each study visit up to the end of the study.<br>

Secondary Outcome Measures

Name	Time	Method

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