Asthma and obstructive sleep apnea. The association, physiological inter-relation and impact of therapy.

The Newcastle Upon Tyne Hospitals NHS Foundation Trusts.0 个研究点目标入组 42 人开始时间: 2016年10月21日最近更新: 2021年5月10日

试验速览

2019 results presented at the European Respiratory Society (ERS) International Congress in https://doi.org/10.1183/13993003.congress-2019.PA890 (added 28/04/2021)

•1. Control group:
•1.1. Normal males or females, who are 18 years or older.
•1.2. No asthma on spirometry and no bronchodilator reversibility.
•1.3. No OSA on sleep study and
•1.4. No other known significant clinical condition according to the clinical assessment of Dr West/Dr Burns
•2. OSA group:
•2.1. Males or females, who are 18 years or older.
•2.2. Significant OSA on sleep study,
•2.3. having empirical CPAP clinically,
•2.4. no asthma on spirometry and no bronchodilator reversibility.
•2.5. No other known significant clinical condition according to the clinical assessment of Dr. West/Dr. Burns
•3. Asthma group:
•3.1. Males or females, who are 18 years or older who have a hospital corroborated clinical diagnosis of asthma.
•4. Asthma with OSA group:
•4.1. Males or females, who are 18 years or older
•4.2. Confirmed asthma and confirmed OSA
•Definitions:
•1. No asthma” means: no history of asthma, normal spirometry and no bronchodilator response
•2. Asthma” means: hospital specialist respiratory physician diagnosis, with history consistent with asthma, previous obstructive spirometry, ratio <70%, minimal smoking history or normal TLCO, (± bronchodilator response if documented previously) without evidence of chronic obstructive pulmonary disease (COPD) i.e. normal gas transfer
•3. Significant OSA” means: oxygen desaturation index of >10 per hour or AHI of >15 per hour on overnight sleep study

•For all groups
•1. Inability to give written informed consent in English.
•2. Where a participant is already involved in other research studies or medical intervention, which might have contraindications for this study.
•3. Patients regarded unfit for any other clinical reason by their respiratory or sleep physician
•4. As the study involve the use of a Pulmonary Function Test (PFT), some individuals with certain conditions should not take a PFT, as it can cause problems. These conditions include:
•4.1. Recent heart attack
•4.2. Heart disease
•4.3.Recent eye surgery
•4.4.Recent chest or abdominal surgery
•4.5.Respiratory infections

发起方

The Newcastle Upon Tyne Hospitals NHS Foundation Trusts.