A Phase II Trial to Examine the Effect of Metformin on Plasma IL-6 Level in Patients With Advanced Non-Small Cell Lung Cancer
试验速览
- 阶段
- 2 期
- 状态
- 终止
- 入组人数
- 13
- 试验地点
- 1
- 主要终点
- The change of plasma IL-6 level after the treatment with metformin
研究概览
简要总结
The purpose of this study is to determine whether metformin is effective in lowering plasma IL-6 level and improving the treatment response in patients with non-small cell lung cancer
详细描述
Interleukin-6 (IL-6) plays an important role in the pathogenesis of lung cancer. Several clinical studies show metformin could decrease IL-6 level in addition to the glucose-lowering effect. Preclinical data also reveal metformin could decrease the IL-6 production in lung cancer cells and enhance cytotoxicity of chemotherapy in animal model. Based on these findings, the purpose of this study is to determine whether metformin is effective in lowering plasma IL-6 level and improving the treatment response in patients with non-small cell lung cancer clinically. Patients with stage IV lung adenocarcinoma will be enrolled in this study and receive standard treatments for lung cancer, either chemotherapy combining cisplatin and pemetrexed or targeted therapy (Gefitinib). For patients with plasma IL-6 more than 2.0 pg/ml after 2 cycles of standard treatment, metformin will be given and titrated to 1500mg/day gradually. Plasma IL-6 level will be checked after use of metformin for 12 weeks. Tumor response to the standard treatment plus metformin will be evaluated and side effects of metformin will also be monitored.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Histologically or cytologically confirmed lung adenocarcinoma.
- •Stage IV disease as defined by AJCC 7th edition staging.
- •At least one measurable lesion (as defined by RECIST v1.1).
- •No prior radiotherapy, chemotherapy, surgery, target therapy, or immunotherapy for NSCLC. (Except the surgery for biopsy or port-A implantation, palliative localized radiotherapy for bone metastasis).
- •Age ≤ 80 years old and ≥ 20 years old.
- •ECOG performance status of 0-
- •Adequate organ function, including followings
- •Bone marrow:
- •Absolute neutrophil count (ANC) ≥ 1.5 x 10^9/L; WBC ≥ 3.0 x 10^9/L Platelet count ≥ 100 x 10^9/L Hemoglobin ≥ 9g/dL
- •Total bilirubin level ≤ 1.0 x UNL AST and ALT ≤ 3.0 x UNL;
- •Creatinine level ≤ 1.5 mg/dL in men, ≤1.4 mg/dL in women; or Estimated CCr ≥ 60 mL/min. (CCr is estimated by Cockcroft-Gault formula, as appendix II)(CCr is estimated by Cockcroft-Gault formula)
- •Estimated life expectancy of at least 6 months.
- •Written (signed) Informed Consent.
排除标准
- •With other primary malignancies, except those remain disease-free for 3 or more years after curative treatment, basal cell cancer of the skin or in situ cervical cancer.
- •Use of other anti-cancer therapy, including chemotherapy, target therapy, immunotherapy, radiotherapy, and hormone therapy.
- •Prior participation in any investigational drug study within 28 days.
- •Use of anti-IL-6 or IL-6-lowering agents.
- •Use of metformin in the past 6 months.
- •Poor controlled diabetes (HbA1c ≥ 8.0%).
- •Known hypersensitivity or intolerance to metformin.
- •Congestive heart failure with NYHA functional class II~IV.
- •History of lactic acidosis.
- •Significant concurrent medical diseases, such as unstable angina, acute or recent myocardial infarction (< 6 months before enrollment), COPD with frequent exacerbation, uncontrolled hypertension, or recent CVA (< 6 months before enrollment).
- •Active uncontrolled infections or HIV infection.
- •Psychiatric disorders that would compromise the patient's compliance or decision.
- •Current or planned pregnancy, or breast feeding in women.
- •Poor compliance.
研究组 & 干预措施
METFORMIN
For patients with stage IV lung adenocarcinoma and IL-6 level higher than 2.0 pg/ml after 2 cycles of standard treatment, metformin 500mg tid orally will be given.
干预措施: METFORMIN (Drug)
结局指标
主要结局
The change of plasma IL-6 level after the treatment with metformin
时间窗: 12 weeks
次要结局
- The objective response rate (RR)(2 YEARS)
- Number of participants with adverse events(2-years)
- Changes of quality of life(2-years)
- The progression free survival(2 years)
- The overall survival(2-years)
研究者
Yu-Min Yeh
MD
National Cheng-Kung University Hospital