Comparison of dexmedetomidine and dexamethasone as adjuvants to levobupivacaine in axillary brachial plexus block
Phase 4
Completed
- Conditions
- Health Condition 1: null- Scheduled for forearm or hand surgery
- Registration Number
- CTRI/2018/04/013158
- Lead Sponsor
- Department of Anesthesia Dayanand Medical College and Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
American Society of Anaesthesiologists (ASA) physical status I and II
Scheduled for surgery on forearm or hand
Exclusion Criteria
Uncooperative patients, psychiatric problems, inability to understand the information provided or inability to give the consent.
Any neurological deficit, peripheral neuropathies, myopathies or chronic pain in the operative limb.
History of anaphylaxis to local anaesthetics or known allergy to any of the study drugs to be used.
Any history of bleeding diathesis or coagulation abnormalities.
Any skin infection or local disease at the needle insertion site.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Time to onset of sensory and motor block. <br/ ><br>Duration of sensory and motor block. <br/ ><br>Duration of analgesia and total analgesic consumption in 24 hours.Timepoint: Onset of sensory and motor block as the time from end of local anesthetic administration to achievement of complete sensory and motor block respectively. <br/ ><br>Duration of sensory block as time from onset of sensory block to return of cold sensation. <br/ ><br>Duration of motor block as time from onset of motor block to return of motor power. <br/ ><br>Duration of analgesia as time from onset of complete sensory block to first intake of rescue analgesia.
- Secondary Outcome Measures
Name Time Method Pain scores <br/ ><br>Adverse effects- Hypotension, Bradycardia, Tachycardia, Hypoxemia, Sedation, Nausea, Vomiting, Pruritis, Skin Rash, Dry mouth, DyspneaTimepoint: Pain assessed by Visual Analogue scale <br/ ><br>Hypotension(noninvasive blood pressure less than 20% of baseline) <br/ ><br>Bradycardia(heart rate less than 60beats/minute) <br/ ><br>Tachycardia(heart rate more than 100beats/minute) <br/ ><br>Hypoxemia(oxygen saturation less than 90%) <br/ ><br>Sedation assessed by Modified Ramsay sedation scale <br/ ><br>Nausea and vomiting assessed by Nausea and vomiting scale.