Staphylococcus Aureus Bacteraemia in Adults
- Conditions
- Staphylococcus Aureus Bacteremia
- Registration Number
- NCT02098850
- Lead Sponsor
- University of Cologne
- Brief Summary
The purpose of this evaluation is to record the management and outcome of adults with S.aureus bacteraemia (SAB) across multiple European, Asian and North American sites and to identify key quality indicators associated with improved outcome.
- Detailed Description
Staphylococcus aureus (S. aureus) is one of the most common causes of bloodstream infections. Associated mortality has been reported to vary widely (4%-40%) although no obvious explanation for such variation has been identified.
Despite the existence of clinical guidelines, there is considerable variation in the management of S.aureus bacteraemia (SAB) between centres. Part of the variation in clinical management is due to the limited evidence base defining optimal therapy. Fewer than 1500 patients have been recruited to randomised controlled trials in the past 40 years; practice is therefore based largely on experience and observational studies.
The purpose of this evaluation is to record the management and outcome of adults with SAB across multiple European, Asian and North American sites. We aim to establish a broader knowledge base, identify key quality indicators associated with improved outcomes, and to provide comparator data to ensure that patients enrolled in randomized controlled trials are representative of bacteraemic S. aureus patients as a whole. All participating centres are experienced in the management of S. aureus bacteraemia and in conducting evaluations of current management practice and outcomes from S. aureus bacteraemia. Data is checked for plausibility by a centralized data quality control group.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 2000
- S. aureus (methicillin sensitive or resistant) isolated from one or more blood cultures
- Recurrent episodes of S. aureus bloodstream infection
- Polymicrobial infection
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Mortality 90 Days
- Secondary Outcome Measures
Name Time Method Length of hospital stay 90 Days
Trial Locations
- Locations (24)
Far Eastern Memorial Hospital
🇨🇳New Taipei City, Taiwan
Uniklinik Koln
🇩🇪Cologne, NRW, Germany
Uniklinik Freiburg
🇩🇪Freiburg, Germany
Seoul National University Bundang Hospital
🇰🇷Seoul, Korea, Republic of
Hospital San Pau
🇪🇸Barcelona, Spain
University Hospital Clinic de Barcelona
🇪🇸Barcelona, Spain
Hospital Vall d'Hebron
🇪🇸Barcelona, Spain
Univeritatklinikum Schleswig-Holstein
🇩🇪Lübeck, Germany
Hospital Universitario Son Espases
🇪🇸Palma. Mallorca, Spain
Salamanca Hospital
🇪🇸Salamanca, Spain
Hospital Universitario Virgen del Rocio
🇪🇸Sevilla, Spain
Hospital Universitario Virgen Macarena
🇪🇸Sevilla, Spain
Birmingham Heartlands Hospital
🇬🇧Birmingham, West Midlands, United Kingdom
Brighton and Sussex University Hospitals
🇬🇧Brighton, United Kingdom
Cambridge University Hospitals
🇬🇧Cambridge, United Kingdom
Royal Liverpool and Broadgreen Hospital
🇬🇧Liverpool, United Kingdom
Hull and East Yorkshire Hospitals
🇬🇧Hull, United Kingdom
Royal Free Hospital
🇬🇧London, United Kingdom
Guy's and St Thomas'
🇬🇧London, United Kingdom
University College London Hospital
🇬🇧London, United Kingdom
Portsmouth Hospitals
🇬🇧Portsmouth, United Kingdom
Kings College Hospital
🇬🇧London, United Kingdom
Plymouth Hospitals
🇬🇧Plymouth, United Kingdom
Oxford University Hospitals
🇬🇧Oxford, United Kingdom