Subcortical Network Connectivity and Temporal Processing in Children With Persistent and Recovered Stuttering
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 500
- 试验地点
- 2
- 主要终点
- Rhythm discrimination (d')
研究概览
简要总结
The specific purpose of this clinical trial is to compare performance on rhythm perception and production tasks between children who stutter and children who do not stutter. The overall project also aims to investigate how performance on rhythm tasks may be related to brain activity (non-clinical trial).
详细描述
Participants in the clinical trial portion of this study will complete rhythm discrimination and finger tapping experiments once a year for 3 years. The study team will compare performance between groups. Participants will also participate in the non-trial portion of the project that includes having magnetic resonance imaging (MRI) each year for 3 years.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 9 Years 至 13 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Children who stutter:
- •English as primary language
- •Current or past stuttering diagnosis
- •Inclusion Criteria Children who do not stutter:
- •English as primary language
排除标准
- •Children who stutter:
- •Diagnosed/under treatment for any neurological or psychiatric conditions
- •Head trauma with loss of consciousness
- •Major medical illness
- •Hearing loss- Language/motor delay (below -2 standard deviations on standardized assessments)
- •Face, motor, or reflex abnormalities
- •Exclusion Criteria Children who do not stutter:
- •Personal or family history of stuttering
- •Diagnosed/under treatment for any neurological or psychiatric conditions
- •Head trauma with loss of consciousness
- •Major medical illness
- •Hearing loss
- •Language/motor delay (below -2 standard deviations on standardized assessments
- •Face, motor, or reflex abnormalities
研究组 & 干预措施
Children who stutter
Children who stutter
干预措施: Rhythm discrimination (Behavioral)
Children who do not stutter
Children who do not stutter
干预措施: Rhythm discrimination (Behavioral)
结局指标
主要结局
Rhythm discrimination (d')
时间窗: Year 3
Performance on the rhythm discrimination task will be assessed using a signal detection analysis to distinguish between participants' ability to discriminate same and different rhythms from any general tendency to respond same or different. Hit rates (HRs) and false alarm rates (FARs) will be obtained to calculate d' (a measure of sensitivity; determined by z(HR) - z(FAR)).
Rhythm discrimination (d')
时间窗: Year 1
Performance on the rhythm discrimination task will be assessed using a signal detection analysis to distinguish between participants' ability to discriminate same and different rhythms from any general tendency to respond same or different. Hit rates (HRs) and false alarm rates (FARs) will be obtained to calculate d' (a measure of sensitivity; determined by z(HR) - z(FAR)).
Rhythm discrimination (d')
时间窗: Year 2
Performance on the rhythm discrimination task will be assessed using a signal detection analysis to distinguish between participants' ability to discriminate same and different rhythms from any general tendency to respond same or different. Hit rates (HRs) and false alarm rates (FARs) will be obtained to calculate d' (a measure of sensitivity; determined by z(HR) - z(FAR)).
次要结局
未报告次要终点
研究者
Soo-Eun Chang
Associate Professor of Psychiatry
University of Michigan