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Impact of Severe Obstructive Sleep Apnea-Hypopnea Syndrome on Auditory-Cognitive Processing

Not yet recruiting
Conditions
Auditory Processing Disorder
Obstructive Sleep Apnea
Registration Number
NCT07039500
Lead Sponsor
Peking University First Hospital
Brief Summary

The goal of this observational study is to learn how severe obstructive sleep apnea-hypopnea syndrome (OSAHS) affects the brain's ability to process sounds and attention in adults aged 20-60 years. The main questions it aims to answer are:

1. Does severe OSAHS change how the brain automatically detects sound changes during wakefulness?

2. Does severe OSAHS reduce people's ability to pay attention to important sounds when awake?

3. Can brainwave tests (Electroencephalogram, EEG) detect early signs of hearing-related cognitive problems in OSAHS patients before symptoms appear?

Researchers will compare two groups:

* 50 adults with severe OSAHS (diagnosed by sleep tests)

* 50 healthy adults matched by age and gender

Participants will:

* Complete hearing tests (MoCA)

* Undergo a 1-night sleep test (PSG)

* Wear an EEG cap for 1.5-2 hours while listening to sounds in a quiet room:

* Passive task: Relax (no response needed)

* Active task: Press a button when hearing rare sounds

* Receive ¥75/hour compensation for their time

Detailed Description

Not available

Recruitment & Eligibility

Status
NOT_YET_RECRUITING
Sex
All
Target Recruitment
100
Inclusion Criteria

All Participants:

  • Aged 20-60 years
  • Normal hearing (PTA ≤25 dB HL at 0.5,1,2,4 kHz; Type A tympanogram)
  • MoCA score ≥26
  • Willing to complete EEG testing

OSAHS Group Additional:

  • PSG-confirmed severe OSAHS (AHI >30 events/hour)

Control Group Additional:

  • Self-reported absence of snoring/sleep disorders
  • No prior OSAHS diagnosis
Exclusion Criteria

All Participants:

  • History of:

    • Schizophrenia, epilepsy, Parkinson's, TBI, or language disorders
    • Middle/inner ear diseases (otitis media, acoustic neuroma, etc.)
    • Cognitive impairment or depression/anxiety disorders
  • Chronic steroid use

  • Systemic inflammatory diseases or malignancies

  • Pregnancy or suspected pregnancy (self-reported)

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Amplitude of Mismatch Negativity (MMN)Day 1

EEG-derived MMN amplitude (microvolts, μV) during oddball task. Lower values indicate impaired automatic sound change detection.

Latency of Mismatch Negativity (MMN)Day 1

EEG-derived MMN latency (milliseconds, ms) during oddball task. Longer values indicate slower automatic processing.

Secondary Outcome Measures
NameTimeMethod
Accuracy in Active Auditory Oddball TaskDay 1

Percentage of correct button presses to deviant sounds (%). Lower values indicate worse performance.

Reaction Time in Active Auditory Oddball TaskDay 1

Time taken to press button after deviant sound onset (milliseconds). Higher values indicate slower processing speed.

Inter-Trial Phase Coherence (ITPC) in Theta/Alpha/Beta BandsDay 1

EEG oscillatory synchronization (range 0-1; 0=no phase consistency). Lower values indicate neural desynchronization during auditory processing.

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