Life Quality and Health in Patients With Klinefelter Syndrome - a Questionnaire Survey
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Aarhus
- Enrollment
- 452
- Locations
- 1
- Primary Endpoint
- Quality of life
Study Overview
Brief Summary
Klinefelter syndrome is the most common sex-chromosome disorder in men with a prevalence of 1 in 660 men. The syndrome is associated with hypogonadism. Many patients with Klinefelter syndrome have psychological complaints and physical discomfort. Some patients report a positive effect of testosterone treatment, whereas others do not.
The aim of this study is:
(i) To investigate quality of life in patients with Klinefelter syndrome. (ii) To investigate functional, physical and mental health in patients with Klinefelter syndrome.
Questionnaire concerning mental and physical health and life quality are sent out to patients with KS and to age-, educational- and zipcode-matched men from the general population. The questionnaire include questions about housing, income, marital status, fatherhood, medication, chronic disease,school and education, attachment to the labor, sexual and erectile function, life quality, mental and physical health, satisfaction with life and symptoms of attention deficits hyperactivity disorders.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Cross Sectional
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Verified Klinefelter syndrome
Exclusion Criteria
- •For the control group:
- •Inclusion Criteria:
- •age-,educational,and residence-matched
- •Exclusion Criteria:
Outcomes
Primary Outcomes
Quality of life
Time Frame: 3 month
Quality of life score is measured with the WHOQOL-Brief questionnaire
Satisfaction with life
Time Frame: 3 month
Satisfaction with life is measured with the SWLS - Satisfaction with Life Scale
ADHD symptoms
Time Frame: 3 month
ADHD symptoms are measured by Adult ADHD Self-Report Scale (ASRS-v1.1) Symptom Checklist
General health
Time Frame: 3 month
General health is measured by SF-36 questionnaire
Erectile function
Time Frame: 3 month
Erectile function is measured by the International index of erectile function (IIEF-5) as a diagnostic tool for erectile function.
Secondary Outcomes
No secondary outcomes reported