Life Quality and Health in Patients With Klinefelter Syndrome

Completed

• Conditions: Klinefelter Syndrome; Quality of Life; Mental Disorders; Physical Disorders

• Registration Number: NCT01690013
• Lead Sponsor: University of Aarhus

Brief Summary

Klinefelter syndrome is the most common sex-chromosome disorder in men with a prevalence of 1 in 660 men. The syndrome is associated with hypogonadism. Many patients with Klinefelter syndrome have psychological complaints and physical discomfort. Some patients report a positive effect of testosterone treatment, whereas others do not.

The aim of this study is:

(i) To investigate quality of life in patients with Klinefelter syndrome. (ii) To investigate functional, physical and mental health in patients with Klinefelter syndrome.

Questionnaire concerning mental and physical health and life quality are sent out to patients with KS and to age-, educational- and zipcode-matched men from the general population. The questionnaire include questions about housing, income, marital status, fatherhood, medication, chronic disease,school and education, attachment to the labor, sexual and erectile function, life quality, mental and physical health, satisfaction with life and symptoms of attention deficits hyperactivity disorders.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Status Verified: 2012-09
• Study Start: 2012-09
• Study First Submitted: 2012-09-11
• Study First Submitted QC: 2012-09-17
• Study First Posted: 2012-09-21
• Primary Completion: 2013-01
• Study Completion: 2014-07
• Last Update Submitted: 2015-05-31
• Last Update Posted: 2015-06-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 452

Inclusion Criteria

• Verified Klinefelter syndrome

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Exclusion Criteria

• none

For the control group:

Inclusion Criteria:

• age-,educational,and residence-matched

Exclusion Criteria:

• none

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Quality of life	3 month	Quality of life score is measured with the WHOQOL-Brief questionnaire
Satisfaction with life	3 month	Satisfaction with life is measured with the SWLS - Satisfaction with Life Scale
ADHD symptoms	3 month	ADHD symptoms are measured by Adult ADHD Self-Report Scale (ASRS-v1.1) Symptom Checklist
General health	3 month	General health is measured by SF-36 questionnaire
Erectile function	3 month	Erectile function is measured by the International index of erectile function (IIEF-5) as a diagnostic tool for erectile function.

Trial Locations

Locations (1)

Medical Department M, Aarhus Universityhospital; 🇩🇰 Aarhus, Denmark