Meso-ORIGINS: An observational study investigating the origins of mesothelioma

Not Applicable

• Conditions: Patients with benign asbestos-associated pleural disease and patients with suspected mesothelioma; Cancer; Malignant neoplasm of lung

• Registration Number: ISRCTN22929761
• Lead Sponsor: HS Greater Glasgow and Clyde

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-08-13
• Last Update Posted: 12 December 2023
• Study Completion: 2027-08-31

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

Arm A:
1. History of asbestos exposure or imaging compatible with this (e.g., pleural plaques)
2. Any form of pleural biopsy within last 1 year showing evidence of associated pleural inflammation (e.g., benign fibrinous pleurisy, non-specific pleuritis, atypical mesothelial proliferation)
3. Informed written consent (to at least banking of previous and future pleural tissue samples)

Arm A MRI sub-study:
1. Registered to the Benign Arm
2. Informed written consent

Arm B:
1. Suspected pleural malignancy, defined by a unilateral pleural effusion or mass
2. History of asbestos exposure or typical radiological features e.g., pleural plaques
3. Sufficient fitness for thoracoscopy (LAT or VATS are permissible)
4. Informed written consent

Exclusion Criteria

Arm A:
1. Any cytologically or histologically confirmed pleural malignancy
2. Any pleural infection including TB
3. Granulomatous pleural inflammation
4. Any specific pleuritis (e.g., RA)
5. Previous Pleurodesis

Arm A MRI sub-study:
1. Any contraindication to MRI, e.g., claustrophobia, pregnancy, metallic foreign body, pacemaker/implant
2. Allergy to gadolinium contrast
3. eGFR <30 ml/min

Arm B:
1. Current or recent (within last 3 months. intercostal chest drain)
2. Previous pleurodesis

Study & Design

• Study Type: Observational
• Study Design: Not specified