Treatment of gum recession

Phase 2/3

Completed

• Conditions: Measurement and Monitoring,

• Registration Number: CTRI/2019/05/019328
• Lead Sponsor: not applicable

Brief Summary

Gingival recession is exposure of the root surface due to apical migration of the gingival margin. It is a common problem in the general population and often leads the patient to seek treatment. Mucogingival therapy may be required to prevent further recession, correct esthetic problems, aid plaque control, and reduce dentin hypersensitivity. The patients today are increasingly conscious of personal appearance and much attention has been focused on denuded roots that are exposed during smiling which look unaesthetic. CAF with SCTG is accepted as the gold standard and has shown greater predictability for obtaining complete root coverage. However, the SCTG technique has some disadvantages. It is time consuming, increases morbidity, requires a second surgery, and leads to postoperative pain and bleeding, and the supply of donor tissue is limited.

PRF is a second-generation platelet concentrate prepared from centrifuged blood. It is a modification of PRP and has some advantages, such as ease of preparation/application, minimal expense, and lack of biochemical modification (no bovine thrombin or anticoagulant is required). Because of PRF’s natural fibrin framework properties, growth factors can maintain their activity for a relatively longer period and effectively stimulate cell migration, wound healing, and tissue regeneration. Recent studies have demonstrated that PRF has a significant slow, sustained release of key growth factors for at least 1 week  and up to 28 days, which means that PRF could stimulate its environment for a significant time during wound healing. It activates the vascular system and releases growth factors involved in soft tissue healing. The PRF membrane can be considered as an effective healing biomaterial. It features all the essential parameters permitting optimal healing. PRF membrane consists of a fibrin 3D mesh polymerized in a specific structure; the incorporation of platelets, leukocytes, and growth factors; and the presence of circulating stem cells. Furthermore, to our knowledge, only one study has tried to compare professional and patient esthetic satisfaction after root-coverage procedures. The results of this study showed that esthetic judgment of the periodontists may not always be consistent with patient satisfaction. Patients were influenced more by the soft-tissue integration variables than by the percentage of root coverage; and patients appeared to rate the cosmetic results more favorably than did the professionals.

             Therefore, the present study will be undertaken to compare the patient related esthetic outcome following Platelet rich fibrin (PRF) membrane with that of Sub epithelial connective tissue graft (SCTG) in Miller Class I and II multiple Gingival recession defects.

Detailed Description

Not available

Study Timeline

• Study Completion: 2019-03-12
• Last Update Posted: 2019-04-12
• Study Start: 2019-05-27

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• 1.Presence of multiple gingival recession (more than one) defects on the labial/ buccal surfaces of the teeth either in maxilla or mandible classified as either Miller’s Class I or II.
• 2.Presence of ≥ 2 mm gingival recession depth 3.Radiographic evidence of sufficient interdental bone (the distance between the crestal bone and cementoenamel junction as ≤ 2mm).
• 4.Presence of adequate width of keratinized gingiva apical to recession.

Exclusion Criteria

• 1.Patients using tobacco products and smokers.
• 2.Un-cooperative patients.
• 3.Patients with unacceptable oral hygiene after phase I therapy and showing plaque score ≥1.
• 4.History of periodontal surgical treatment in quadrant selected for the study.
• 5.Pregnant lady or lactating mother.
• 6.Presence of badly caries teeth 7.Presence of mobile teeth.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Patient centered/ Subjective	Baseline, one week, one month, 3 months and 6 months

Secondary Outcome Measures

Name	Time	Method
gain in CAL	one week, one month, 3 months and 6 months

Trial Locations

Locations (1)

Sharad Pawar Dental College; 🇮🇳 Wardha, MAHARASHTRA, India

Sharad Pawar Dental College

🇮🇳Wardha, MAHARASHTRA, India

Dr Ruchika Lulla

Principal investigator

7588752199

ruchika.lulla@gmail.com