Prospective Randomized Trial Comparing Nitrous Oxide and Carbon Dioxide for Laparoscopic Cholecystectomy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 64
- 试验地点
- 1
- 主要终点
- heart rate
研究概览
简要总结
There is no general agreement about the ideal gas for pneumoperitoneum. CO2, now in common use, has not compared to N2O sufficiently to disclose which one has minimal "physiological" invasiveness characters. Assigned randomly to carbon dioxide or nitrous oxide group, the hemodynamic and respiratory parameters (heart rate, mean arterial blood pressure, end-tidal CO2, minute ventilation, and O2 saturation) before pneumoperitoneum and during it were recorded. Pain, as perceived by patients, is measured 2, 4 and 24 hours after the procedure by visual analogue scale. Vomiting and use of analgesics and antiemetics were recorded and compared.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- — 至 65 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •developed gallstones
- •candidates for laparoscopic cholecystectomy
- •written informed consent
- •ASA Score = 1&2
排除标准
- •signs and complications of gallstones in admission include acute cholecystitis and suppurative cholangitis
- •complete Inability to move
- •severe physical or mental disorders leading to inability to communicate -Pregnancy and
结局指标
主要结局
heart rate
时间窗: At the start of laparoscopic surgery and Immediately after surgery.
number of heartbeats per minute measured in At the start of laparoscopic surgery and Immediately after surgery.
次要结局
- Mean arterial pressure(At the start of laparoscopic surgery and Immediately after surgery.)
研究者
Mehdi Asgari
Principal Investigator
Ahvaz Jundishapur University of Medical Sciences