The Comparison of Microbial Adherence to Various Sutures in Patients Undergoing Oral Surgery
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 主要终点
- bacterial counts on blood agar plates from each suture will be quantified in CFU (colony-forming units) and expressed as total bacteria/suture
研究概览
简要总结
The final stage of any surgical procedure is suturing. Sutures have a vital rule in wound healing- they are responsible for flaps approximation, hemostasis and restoring function and esthetics.
Choosing the right suture is crucial especially in oral sites because of its unique anatomical features: the presence of saliva and the patient's everyday function- swallowing, talking, eating etc.
Sutures require certain physical properties such as tensile strength, dimensional stability, lack of memory, knot security and elasticity. One highly important quality is the ability to prevent or reduce bacterial adhesion and by that to prevent secondary infection. There are many kinds of sutures in the market- none of which contains all the ideal features.
The aim of the study is to compare the amount of bacterial adhesion to different kinds of sutures in patients undergoing periodontal surgery.
详细描述
The participates in the study are scheduled to go oral surgery: dental implantation, Guided bone regeneration, resective periodontal surgery, sinus elevation (both crestal or lateral).
All participates will sign an informed consent form and under the institutional ethics committee approval will go to through the operation.
Each surgery will include at least 4 Simple Interrupted Suture with even spacing of 5 mm from each other in the scheduled for operation and without changing the original treatment plan. Incision location is in the area of surgery and not in a distinct location. The four sutures that will be used are: silk, vicryl, nylon and polypropylene.
At suture removal, after 10 days, all sutures will be collected in a sterile tube containing PBS solution. Within 3 hours, the samples will be sowed on two blood agar media plates. One plate will be aerobic condition and the other in an-aerobic condition. After one week, the number of colonies will use to calculate the CFU- colony-forming units.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients designated for oral surgery with the possibility to perform at least 4 sutures, 5mm apart. The surgery will take place at the periodontology department, Dental faculty, Hadassah medical center.
- •Patients willing to participate in the study and sign an informed concerned form
- •Patients without systemic illness
排除标准
- •Diabetes, heart disease, immune deficiency, thrombocytopenia\ coagulation enzymes deficiency
- •Chronic alcohol consumption\ drug user
- •Pregnancy
研究组 & 干预措施
silk suture
silk suture
干预措施: silk suture (Other)
vicryl suture
vicryl suture
干预措施: vicryl suture (Other)
nylon suture
nylon suture
干预措施: nylon suture (Other)
polypropylene suture
polypropylene suture
干预措施: polypropylene suture (Other)
结局指标
主要结局
bacterial counts on blood agar plates from each suture will be quantified in CFU (colony-forming units) and expressed as total bacteria/suture
时间窗: Outcome measure will be assessed 10 days after sample incubation for the different sutures obtained from each study participate
CFU from all four different sutures (silk, vicryl, nylon and polypropylene sutures) will be compared.
次要结局
未报告次要终点