efficacy of supraglottic and subglottic instillation of dexamethasone or dexmedetomidine for the incidence and severity of postoperative sore throat after general anaesthesia

After enrolment in the study with the consent of thepatients, they will be assessed preoperatively. All patients will be NPO 8 hrsbefore operation. All thesubjects will be divided into two groups, Group A and Group B in the ratio of1:1 according to random number table. All Patients and anaesthetists will beblinded to group assignments. On bringing the patient to operating room, baseline recording of ECG, SBP, DBP, MBP, HR, RR will be measured using themonitor. The vein channel is to be established during a 18G indwelling needle.A simple face mask will be used for Oxygen for 3 minutes. Then anaesthesia willbe induced through intravenous injection of 2ug/kg Fentanyl, 2mg/kg Propofoland 0.5mg/kg Atracurium/injVecuronium(0.1mg/kg). Afterthree minutes of IPPV, intubation will be performed bydirect laryngoscopy using appropriate size endotracheal tube. A single use highvolume low pressure cuffed ETtube (Tuoren) containing supra & subglotticport for drug instillation will be used for intubation which will be fixed andinflated by 3-5ml of air.After securing ETtube a total volume of 5ml drug (8mgdexamethasone diluted in 3ml normal saline or 100mcg dexmeditomidine diluted in3ml normal sline) will be given in supra & subglottic area through  supra & subglottic port of ET tube(Tuoren).