The Effect of Direct Antiviral Therapy on Hepatitis c Virus-related Thrombocytopenia
试验速览
- 阶段
- 不适用
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- the mean difference on the platelet count
研究概览
简要总结
Autoimmune thrombocytopenic purpura is an immunological disorder characterized by increased platelet destruction due to presence of anti-platelet antibodies. Hepatitis C virus infection, which is one of the most common chronic viral infections worldwide, may cause secondary chronic immune thrombocytopenic purpura. It seemed to play a pathogenic role in autoimmune thrombocytopenic purpura. Moreover, the successful response (negative hepatitis C virus - ribonucleic acid) to tapered steroids and antiviral therapy was useful to revert thrombocytopenia
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Hepatitis C virus infection and thrombocytopenia before treatment
排除标准
- •Infection Hepatitis B virus
- •Hypersplenism
- •Diseases affecting Bone marrow
- •Major clotting factors abnormalities eg. Disseminated intravascular coagulopathy, severe Prothrombin deficiency
研究组 & 干预措施
study group
Hepatitis- C virus with thrombocytopenia
干预措施: Ledipasvir/sofosbuvir (Drug)
study group
Hepatitis- C virus with thrombocytopenia
干预措施: sofosbuvir daclatasvir (Drug)
结局指标
主要结局
the mean difference on the platelet count
时间窗: 6 month
次要结局
未报告次要终点
研究者
Ahmed Mohamed Abbas
principal investigator
Assiut University