Effects of Kampo medical formula for the blood circulation in the eye with healthy subjects

Not Applicable

• Conditions: healthy subjects

• Registration Number: JPRN-UMIN000012580
• Lead Sponsor: Tohoku university

Brief Summary

A crossover protocol was used to randomly administer five grams of yokukansan, tokishakuyakusan (TSS), keishibukuryogan, or hachimijiogan to 13 healthy blinded subjects (mean age: 37.3 years). The mean blur rate, a quantitative OBF index obtained with laser speckle flowgraphy, was measured at the optic nerve head before and 30 minutes after administration. Blood pressure (BP) and intraocular pressure (IOP) were also recorded. No significant changes were observed in mean BP or IOP after the administration of any of the kampo medical formulas. There was a significant increase in OBF 30 minutes after administration of TSS (100% to 103.6 %, p < 0.01). Next, TSS was administered to 19 healthy subjects (mean age: 32.0 years) and OBF was measured before and 15, 30, 45, and 60 minutes after administration. Plain water was used as a control. OBF increased significantly after TSS administration compared to control (p < 0.01) and also increased from 30 to 60 minutes after administration compared to baseline (p < 0.05).

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-12-16
• Study Completion: 2014-01-05
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Not provided

Exclusion Criteria

Intra ocular pressure => 22 mmHg Abnormality in funduscopy With the history of surgery to the eye With HT or DM With the history of smoking hanits

Study & Design

• Study Type: Interventional
• Study Design: Not specified