Obstructive Sleep Apnea in Pulmonary Embolism

Completed

• Conditions: Pulmonary Thromboembolism; Obstructive Sleep Apnea
• Interventions: Other: polysomnography

• Registration Number: NCT01580085
• Lead Sponsor: University of Gaziantep

Brief Summary

Obstructive sleep apnea (OSA) is a clinical syndrome characterized by repetitive closure of the airway and frequent awakenings during sleep. Repeated episodes of hypoxia, decrease in intrathoracic pressure, increased venous return and venous stasis, damage to vascular wall may ensue. An increased tendency for coagulation has also been reported in OSA. Venous stasis, vascular endothelial activation and hypercoagulability are also known risk factors for thromboembolism. All of these pathophysiologic changes in OSA may predispose patients for the development of pulmonary embolism (PE) however there is limited data about role of thromboembolic events in OSA.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-11
• Primary Completion: 2010-12
• Study Completion: 2010-12
• Status Verified: 2012-04
• Study First Submitted: 2012-04-16
• Study First Submitted QC: 2012-04-17
• Last Update Submitted: 2012-04-17
• Study First Posted: 2012-04-18
• Last Update Posted: 2012-04-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

• All consecutive patients diagnosed with pulmonary embolism

Exclusion Criteria

• less than 18 years of age
• any restrictive or obstructive lung disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Pulmonary embolism	polysomnography	Patients who were diagnosed with pulmonary embolism
control group	polysomnography	age and sex matched adults with osa and no thromboembolism

Trial Locations

Locations (1)

University of Gaziantep Hospital; 🇹🇷 Gaziantep, Turkey