Effect Of Intermittent Fasting 5: 2 To Waist Circumference, Insulin Resistance And Oxidative Stress Marker In Obese Workers In Jakarta
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 62
- 试验地点
- 1
- 主要终点
- catalase level
研究概览
简要总结
The world prevalence of obesity in adult population in 2016 was 650 million while in Indonesia, it has increased from 14,8 percent to 21,8 percent in 2018. Obesity is an established risk factors for metabolic and non communicable- diseases. The purpose of this research was to assess the different effect on waist circumference, insulin resistance and oxidative stress marker between fasting (intervention) group and not fasting (control) group after 8 weeks 5:2 intermittent fasting (IF) among obese male workers.
详细描述
Intermittent fasting is eating pattern in that cycles between periods of fasting and eating. 5:2 intermittent fasting (IF) is a form of time-restricted fasting which no calories are consumed for at least 14 hours (for 4 am to 6 pm) will done in two non-consecutive days days per week, followed by ad libitum intake on the remaining days, with water restriction too.
Participants will be distributed to each group by simple randomization. This study will access the characteristic data, dietary intake and physical activity from the participants. Anthropometry and blood sample (for insulin resistance (HOMA-IR) and oxidative stress (malondialdehyde and catalase)) were taken at baseline and at the end of the study. Participants from each group will gets counseling at the second week of intervention and they will follow up to 8 weeks with control and evaluation form.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 59 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Men aged 30-59 years
- •Has a BMI ≥ 25 kg/m^2
- •Has a waist circumference of ≥ 90 cm
- •Willingness to participate in the whole study by signing informed consent
排除标准
- •Doing regular fasting (2 days a week) for 12 weeks before the study begins.
- •In a certain diet at the moment
- •Participants who are taking drugs that can affect blood sugar, insulin, and drugs (steroids, beta blockers, adrenergics), vitamins or herbal supplements and other drugs that affect oxidative stress.
- •Participants suffering from obesity with complications such as impaired liver function, impaired kidney function, heart disease and type 2 diabetes mellitus are known through anamnesis and physical examination as well as fasting blood sugar checks.
- •Participants that has a fever with temperatures> 37.5 ℃
研究组 & 干预措施
intervention
Participants will ask to do 5:2 intermittent fasting (2 non-consecutive days a week) within 8 weeks
干预措施: Fasting (Behavioral)
control
Participants will not doing fasting or intake restriction within 8 weeks
结局指标
主要结局
catalase level
时间窗: 8 weeks
Enzymatic antioxidant status of endogenous catalase in the blood, expressed in U/mg
insulin resistance
时间窗: 8 weeks
The pathological condition in which cells fail to respond normally to the hormone insulin. Assessed based on the HOMA-IR value
plasma malondialdehyde level
时间窗: 8 weeks
the concentration of malondialdehyde (1,3-Propanedial) in the plasma as an oxidative stress marker measured by means of Will's method expressed in nmol/ml plasma unit
waist circumference
时间窗: 8 weeks
One way of anthropometry measurement to assess the visceral fat mass, so that it can evaluate the risk of metabolic disease. expressed in centimeter.
次要结局
- mean caloric intake(8 weeks)
研究者
Anni Rahmawati
Student
Indonesia University