The Moderating Roles of Social Support, Coping Resources and Personality and Mediating Role of Self-esteem on the Impact of Cognitive Deficit on Neuropsychiatric Symptoms Among Persons With Mild Cognitive Impairment: A Mixed-method Sequential Explanatory Design
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Mild Cognitive Impairment
- Sponsor
- Chinese University of Hong Kong
- Enrollment
- 152
- Locations
- 1
- Primary Endpoint
- Hong Kong Chinese version of Montreal Cognitive Assessment (HK-MoCA)
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
This is a sequential mixed study to test the hypothesized models with seven hypotheses of the relationship between cognitive deficit (subject and objective) and neuropsychiatric symptoms (NPS) among persons with mild cognitive impairment (PwMCI). The study will also examine the psychometric properties of the Chinese version of Mild Behavioural Impairment -Checklist (MBI-C).
Detailed Description
The primary aim of this study is to test the hypothesized model that explores the moderating roles of neurotic personality, social support and coping style, as well as the mediating role of self-esteem in the relationship between cognitive deficit and NPS. This study will also examine the psychometric properties of the Chinese version of MBI-C. Specifically, the four objectives of this study are as follows: 1. To examine the relationship between cognitive deficit (subjective and objective) and NPS 2. To examine the moderating roles of the neurotic trait (neuroticism) and coping resources (coping style and social support), as well as the mediating role of self-esteem in the relationship between cognitive deficit and NPS 3. To explore the life experience of PwMCI that help to determine how these factors moderate/ mediate the relationship between cognitive deficit and NPS 4. To examine the psychometric properties of the Chinese version of MBI-C among PwMCI in Hong Kong This sequential mixed study will be conducted in two non-governmental organization in Hong Kong. For the first and second objective, a descriptive, cross-sectional, correlational approach will be adopted to test the hypothesized models with seven hypotheses of the relationship between cognitive deficit (subject and objective) and NPS. The moderating roles of personality trait (neuroticism) and coping resources (coping styles and social support), as well as the mediating role of self-esteem in such a relationship, will also be explored. For the third objective, semi-structured interviews will be adopted to explore the life experience of PwMCI, which help understanding how the proposed factors mediate or moderate the relationship between compromised abilities and NPS. For the fourth objective, the psychometric properties of the Chinese version of MBI-C will be examined and reported. Internal consistency, 2-week test-retest reliability, factorial validity, concurrent validity and convergent validity will be assessed.
Investigators
Rose Sin Yi Lin
Principal Investigator
Chinese University of Hong Kong
Eligibility Criteria
Inclusion Criteria
- •Aged 18 years old or above
- •Able to communicate in Cantonese
- •Diagnosis with MCI as defined by the following criteria:
- •Presence of significant cognitive complaints, as defined by more than three complaints on the Memory Inventory for Chinese (MIC), which is a 27-item instrument measuring subjective memory deficit
- •Abnormal objective cognitive performance defined as \< 1.5 standard deviations from age and education matched normal persons on Hong Kong Chinese version of Montreal Cognitive Assessment (HK-MoCA), which is a 12-item instrument measuring cognitive functions
- •Independence in daily living as evaluated through clinical interview
- •Both patients and one of their guardian or family members are consented to participate in the study
Exclusion Criteria
- •With the confirmed diagnosis of any forms of dementia
- •With the confirmed diagnosis of psychiatric morbidities, or history with stroke, brain injury and other neurological conditions that may affect cognitive, behavioural and emotional functioning which may confound outcome measurement and limit their participation in the study
- •With hearing or visual impairment that may hinder participation in research activities
- •Current use of cognitive intervention or electromagnetic stimulation
Outcomes
Primary Outcomes
Hong Kong Chinese version of Montreal Cognitive Assessment (HK-MoCA)
Time Frame: Baseline
This 12-item instrument will be used to measure cognitive functions including visuospatial functions, naming, verbal memory, abstraction, delay memory, calculation and orientation. Total score ranges from 0 to 30, with lower scores indicating more severe cognitive impairment.
Chinese Version of the Neuropsychiatric Inventory Questionnaire (NPI-Q)
Time Frame: Baseline
NPI-Q is a caregiver-administered instrument that assesses measure the frequency and severity of NPS among the participants.This instrument measures 12 domains including delusion, hallucination, anxiety, depression, euphoria, apathy, disinhibition, irritability and aberrant motor behaviour, sleep disturbance and appetite. The instrument will be completed by an informant to rate the frequency of NPS on a four-point scale (1 - sporadically, 4 - very often) and the severity of NPS on a three-point scale (1 - mild, 3 - severe).
Chinese version of Chinese version of Mild Behavioural Impairment -Checklist
Time Frame: Baseline
This 34-item questionnaire will be used to measure five domains of NPS, including decreased motivation, emotional dysregulation, impulse dyscontrol, social inappropriateness and abnormal perception or thought content. It involves closed-ended questions on the existence of symptoms followed by a 3-point Likert scale on their severity. Total scores of all domains range from 0 to 102, with higher scores indicating more NPS.
Secondary Outcomes
- Chinese version of Simplified Coping Scale Questionnaire (SCSQ)(Baseline)
- Chinese version of Multidimensional Scale of Perceived Social Support (MSPSS-C)(Baseline)
- Chinese version of the neuroticism subscale of NEO Personality Inventory (NEO-PI)(Baseline)
- Rosenberg self-esteem scale (RSES)(Baseline)