Use of Nitric Oxide Metabolites for Predicting Embryo Quality in In-Vitro Fertilization (IVF)

Not Applicable

Terminated

• Conditions: Infertility
• Interventions: Procedure: Transfer of embryos on day 3 or day 5 after fertilization.; Procedure: Day 5 transfer

• Registration Number: NCT00788619
• Lead Sponsor: Johns Hopkins University

Brief Summary

Improvements in In-Vitro Fertilization (IVF) outcomes have largely been due to the generation of excess embryos allowing for multiple embryo transfer. Unfortunately this has also increased the risk of multiple pregnancy with associated maternal and neonatal morbidity and mortality. The investigators believe that the concentration of nitric oxide metabolites measured in the culture medium from the first day of culture can identify the best quality embryos allowing us to transfer a limited number of embryos without compromising the optimum chance for pregnancy.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2008-11-10
• Study First Submitted QC: 2008-11-10
• Study First Posted: 2008-11-11
• Study Start: 2009-01
• Primary Completion: 2009-10
• Study Completion: 2009-10
• Status Verified: 2017-12
• Last Update Submitted: 2017-12-07
• Last Update Posted: 2017-12-11

Recruitment & Eligibility

• Status: TERMINATED
• Sex: Female
• Target Recruitment: 2

Inclusion Criteria

• Age 21-37
• Female
• Less than two previous unsuccessful IVF cycles

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Exclusion Criteria

• Day 3 FSH >9.9
• Fewer than 8 mature oocytes retrieved
• Fewer than 8 normally fertilized embryos on day 2 after fertilization

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Day 3 transfer	Transfer of embryos on day 3 or day 5 after fertilization.	Subjects in this arm will have two embryos transferred three days after fertilization. Embryos will be selected based on the concentration of nitric oxide metabolites in the culture medium.
Day 5 transfer	Day 5 transfer	Subjects will have two embryos transferred on day 5 after fertilization with selection of embryos based on morphologic criteria.

Primary Outcome Measures

Name	Time	Method
Percentage of subjects with viable pregnancy one month after embryo transfer	1 month

Secondary Outcome Measures

Name	Time	Method
Percentage of subjects with > 2 viable embryos one month after embryo transfer	1 month

Trial Locations

Locations (1)

Johns Hopkins Fertility Center; 🇺🇸 Lutherville, Maryland, United States