High-intensity Interval Training in Patients With Post-acute Coronary Syndrome

Not Applicable

Completed

• Conditions: Acute Coronary Syndrome; Arrhythmia

• Registration Number: NCT03414996
• Lead Sponsor: Montreal Heart Institute

Brief Summary

To date, no studies have evaluated the safety or efficiency (improvement of maximal oxygen uptake \[VO2peak\]) of a high-intensity interval training (HIIT) program in post-acute coronary syndrome (post-ACS) patients. Heart rate variability (HRV) and recovery (HRR), QT dispersion (QTd) and ventricular arrhythmias are all indices associated with an increased risk of cardiac death. HIIT has been shown to improve these risk markers and be safe in coronary heart disease patients but not yet in post-ACS patients which are considered more at risks.

The aim of this study was to compare a HIIT program to a moderate-intensity continuous exercise training (MICET) program on HRV, HRR, QTd parameters and occurrence of ventricular arrhythmias in post-ACS patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-01-01
• Primary Completion: 2014-06-30
• Study First Submitted: 2018-01-23
• Study First Submitted QC: 2018-01-23
• Study First Posted: 2018-01-30
• Study Completion: 2021-12-30
• Status Verified: 2022-09
• Last Update Submitted: 2022-09-09
• Last Update Posted: 2022-09-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Males or females aged ≥ 18 years
• Acute coronary syndrome within 6 weeks (unstable angina, or non-ST elevation myocardial infarction (NSTEMI), or ST elevation myocardial infarction (STEMI with the presence of 2/3 criteria (i.e. typical chest pain, electrocardiographic ischemic change or elevated troponin T
• Complete revascularization defined as no major epicardial coronary artery or bypass graft with a residual diameter stenosis >50% and no residual left main stenosis ≥40%
• Left ventricular ejection fraction >40%
• Stable doses of medication during the 4 weeks prior to enrolment (STEMI patients must be on a stable dose of beta-blocker)
• Able to perform a maximal cardiopulmonary exercise test, 7) capacity and willingness to sign informed consent.

Exclusion Criteria

• Recent coronary bypass surgery (<6 months)
• Incomplete revascularisation, left ventricular ejection fraction <40%
• Significant valvular disease (mitral stenosis, moderate to severe mitral insufficiency, aortic stenosis, or aortic insufficiency)
• Uncontrolled hypertension (systolic blood pressure/diastolic blood pressure >180/110 mmHg)
• Significant resting electrocardiogram abnormalities (left bundle branch block, non-specific intraventricular conduction delay, left ventricular hypertrophy, resting ST-segment depression)
• Chronic atrial fibrillation
• Pacemaker or implantable cardioverter defibrillator
• Low functional capacity (<5 basal Metabolic Equivalent of Task [METs])
• Change of cardiac medications within 4 weeks of enrolment and any contraindication to exercise testing or exercise training.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Maximal oxygen uptake	At baseline and following 12 weeks exercise training intervention	Change before and after exercise training

Secondary Outcome Measures

Name	Time	Method
Markers of autonomic nervous system	At baseline and following 12 weeks exercise training intervention	Change before and after exercise training

Trial Locations

Locations (1)

Cardiovascular prevention and rehabilitation center; 🇨🇦 Montreal, Quebec, Canada