DRKS00007781已完成未知
Effect of dietary lipid modification on nonalcoholic fatty liver disease in carriers of the PNPLA3 I148M genetic variant: an open label trial
Saarland University Medical Center0 个研究点目标入组 20 人开始时间: 2015年3月25日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 20
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- N/a: Single Arm Study
- 盲法
- Open (masking not used)
入排标准
- 年龄范围
- 18 Years 至 one（—）
- 性别
- All
入选标准
- •1. Patients with non-alcoholic fatty liver disease
- •2. Patients with the PNPLA3-Genotype (p.148MM and p.I148II)
排除标准
- •Known infection with viral hepatitis, HIV or cholestatic liver diseases (e.g. PBC, PSC).
- •Presence of Diabetes Mellitus Type 2 (HbA1c = 7.5% (= 58 mmol/mol)
- •Presence of Alcoholic Fatty Liver Disease
- •with a weekly alcohol consumption of > 21 drinks (> 30 g alcohol/Day) in men and >14 drinks (> 20 g alcohol/Day) in women (2)
- •Presence of liver cirrhosis based on liver stiffness measurement (transient elastography = 13kPa FibroScan®,Echosens, Paris, France)
- •Medications known to increase fatty liver (e.g. Amiodarone, Methotrexat) or to affect carbohydrate or lipid metabolism?
- •Vegetarians or vegans
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