Risk Factors for ARDS in Patients With Acute Necrotizing Pancreatitis

Completed

• Conditions: Acute Respiratory Distress Syndrome; Acute Necrotizing Pancreatitis

• Registration Number: NCT02641964
• Lead Sponsor: Nanjing Medical University

Brief Summary

Try to collect about 350 cases of acute necrotizing pancreatitis at the First Affiliated Hospital with Nanjing Medical University and Nanjing General Hospital of Nanjing Military Command. Then the investigators studied the incidence and the risk factors of ARDS in patients with acute necrotizing pancreatitis.

Detailed Description

Using electronic patient data monitoring systems, the investigators reviewed all patients with a diagnosis of pancreatitis admitted to surgical wards or ICUs at the First Affiliated Hospital with Nanjing Medical University and Nanjing General Hospital of Nanjing Military Command from January 1, 2009, to October 31, 2015. Inclusion criteria were adult patients (age \>18 years) with acute necrotizing pancreatitis. Exclusion criteria were as follows : 1) lack of radiologic evidence to diagnose acute necrotizing pancreatitis, 2) presence of ARDS before admission to hospitals, 3) unable to partner treatment and leaving hospitals, 4) transferring to the investigators' hospitals after treatment, 5) missing other necessary data, and 6) pregnancy.

For enrolled patients, general clinical characteristics were collected. Patients were categorized into two groups according to ARDS or non-ARDS, and the differences of these characteristics between two groups were evaluated. Potential risk factors were collected and studied by using multiple logistic regression analysis.

Study Timeline

• Study Start: 2015-11
• Study First Submitted: 2015-12-08
• Study First Submitted QC: 2015-12-25
• Study First Posted: 2015-12-30
• Status Verified: 2021-01
• Primary Completion: 2021-01
• Study Completion: 2021-01
• Last Update Submitted: 2021-01-22
• Last Update Posted: 2021-01-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 350

Inclusion Criteria

• Adult patients (age >18 years) with acute necrotizing pancreatitis

Exclusion Criteria

• lack of radiologic evidence to diagnose acute necrotizing pancreatitis,
• presence of ARDS before admission to hospitals,
• unable to partner treatment and leaving hospitals,
• transferring to the investigators' hospitals after treatment,
• missing other necessary data,
• pregnancy.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
the incidence of ARDS in patients with acute necrotizing pancreatitis	up to 2 months

Secondary Outcome Measures

Name	Time	Method
the risk factors for ARDS in patients with acute necrotizing pancreatitis	up to 2 months	Potential risk factors included smoking, alcohol abuse, diabetes mellitus, abdominal surgery, shock, hypoalbuminaemia, hypertriglyceridemia and hypercholesterolemia.Univariate analyses examined potential risk factors on outcome (ARDS or non-ARDS). Then, using multiple logistic regression analysis, factors achieving P≤0.1 in univariate analyses were entered into the model predicting the risk for the onset of ARDS.